Tue Dec 08 2015 18:58:23 GMT+0100 (CET)2025-06-05 12:26:29
description
cell shape-determining protein, forms filaments, the polymers control/restrict the mobility of the cell wall elongation enzyme complex, required for LytE activity
[SW|cell shape]-determining protein, forms filaments, the polymers control/restrict the mobility of the cell wall elongation enzyme complex, required for [[protein|LytE]] activity
locus
BSU14470
BSU_14470
function
cell shape determation
[SW|cell shape] determation
product
cell shape-determining protein
[SW|cell shape]-determining protein
ec
outlinks
bsu
BSU14470
BSU_14470
[SW|Categories] containing this gene/protein
[SW|cell shape], [SW|heat shock proteins], [SW|membrane proteins]
Gene
Coordinates on the chromosome (coding sequence)
1,516,574 -> 1,517,581
The protein
Protein family
ftsA/mreB family (according to Swiss-Prot)
[SW|FtsA/MreB family] (according to UniProt)
The protein
Paralogous protein(s)
[[protein|MreB]], [[protein|Mbl]]
[[this]]
The protein
[SW|Localization]
during logarithmic growth, [SW|MreBH] forms discrete patches thst move processively along peripheral tracks perpendicular to the cell axis [Pubmed|21636744]
forms transverse bands as cells enter the stationary phase [Pubmed|21636744]
close to the inner surface of the cytoplasmic membrane [Pubmed|16950129]
reports on helical structures formed by MreBH [Pubmed|16950129,20566861] seem to be misinterpretation of data [Pubmed|21636744]
normal localization depends on the presence of glucolipids, [[protein|MreB]] forms irregular clusters in an ''[[protein|ugtP]]'' mutant [Pubmed|22362028]
during logarithmic growth, [[protein|MreBH]] forms discrete patches thst move processively along peripheral tracks perpendicular to the cell axis [Pubmed|21636744]
forms transverse bands as cells enter the stationary phase [Pubmed|21636744]
close to the inner surface of the cytoplasmic membrane [Pubmed|16950129]
reports on helical structures formed by MreBH [Pubmed|16950129,20566861] seem to be misinterpretation of data [Pubmed|21636744]
normal localization depends on the presence of glucolipids, [[protein|MreB]] forms irregular clusters in an ''[[gene|ugtP]]'' mutant [Pubmed|22362028]
The protein
[SW|Interactions]
part of the [SW|cell wall biosynthetic complex] [Pubmed|21636744,21636745]
[SW|MreBH]-[[protein|LytE]] [Pubmed|16950129]
[SW|MreBH]-[[protein|Mbl]] [Pubmed|21636744]
[[protein|MreB]]-[SW|MreBH] [Pubmed|17064365]
[[protein|RodZ]]-[SW|MreBH] [Pubmed|23879732]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigI]] [Pubmed|18156261]
Expression and Regulation
Regulation
expression is increased in an ''[[protein|ugtP]]'' mutant [Pubmed|22362028]
induced at high temperature ([[protein|SigI]], [[protein|WalR]]) [Pubmed|24125693,18156261]
Expression and Regulation
Regulatory mechanism
[[protein|WalR]]: transcription activation [Pubmed|24125693]
References
Other original publications
proteinLength
335
geneLength
1008
Gene
Coordinates
1,516,574 1,517,581
The protein
Structure
[PDB|1JCF] ([[protein|MreB]] from ''Thermotoga maritima'', 52% identity) [Pubmed|11544518]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE14470 ([[gene|mreBH]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE14470 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTTTCACCCAATCTCT, downstream forward: _UP4_TAGTCTTTACCCGCAAAATT
BKK14470 ([[gene|mreBH]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK14470 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTTTCACCCAATCTCT, downstream forward: _UP4_TAGTCTTTACCCGCAAAATT