2017-8-11 16:0:3Tue Dec 13 2016 11:16:31 GMT+0100 (CET)
proteinLength
458
geneLength
1374
Gene
Coordinates
882,266 → 883,642
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-C351 (acoL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2349 NBRP B. subtilis, Japan]
aminos
MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCIPTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKKNQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDSKDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQEKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLEQAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKINEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIMAEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLSTIGLAVHA
[SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|sporulation proteins]
Gene
Coordinates on the chromosome (coding sequence)
882,266 -> 883,642
The protein
[SW|Interactions]
([[protein|AcoA]]-[[protein|AcoB]])-[[protein|AcoC]]-[[protein|AcoL]]
Expression and Regulation
Operon
''[[protein|acoA]]-[[protein|acoB]]-[[protein|acoC]]-[[protein|acoL]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/11274109 PubMed]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigL]] [http://www.ncbi.nlm.nih.gov/sites/entrez/11274109 PubMed]
Expression and Regulation
Regulation
repressed by glucose ([[protein|CcpA]]) [Pubmed|10666464]
induced by acetoin ([[protein|AcoR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/11274109 PubMed]
induced under anaerobic conditions ([[protein|Fnr]]) [Pubmed|16428414]
Expression and Regulation
Regulatory mechanism
[[protein|CcpA]]: transcription repression [Pubmed|10666464]
[[protein|AcoR]]: transcription activation (interaction with [[protein|SigL]]-containing [SW|RNA polymerase]) [http://www.ncbi.nlm.nih.gov/sites/entrez/11274109 PubMed]
[[protein|Fnr]]: indirect positive regulation via [[protein|NarG]]-[[protein|NarH]]-[[protein|NarJ]]-[[protein|NarI]] [Pubmed|16428414]
Expression and Regulation
Additional information
the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
the mRNA is substantially stabilized upon depletion of [[Rny|RNase Y]] [PubMed|21815947]