Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)2025-05-12 13:09:31
description
toxic peptide
toxic peptide, eliminates defective cells from developing biofilms
locus
BSU26050
BSU_26050
ec
names
txpA
yqcR
yqdB
txpA
yqcR
outlinks
bsu
BSU26050
BSU_26050
[SW|Categories] containing this gene/protein
[SW|toxins, antitoxins and immunity against toxins], [SW|Skin element], [SW|membrane proteins]
Gene
Coordinates on the chromosome (coding sequence)
2,678,240 -> 2,678,419
The protein
[SW|Localization]
cell membrane
cell membrane (according to UniProt)
Expression and Regulation
Operon
''txpA'' [Pubmed|16166525]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|16166525]
Expression and Regulation
Regulatory mechanism
expression is prevented by the ''[[protein|ratA]]'' antisense RNA [Pubmed|16166525]
the ''[[protein|txpA]]'' mRNA-''[[protein|RatA]]'' RNA duplex is degraded by [[rnc|RNase III]] [Pubmed|23300471]
Expression and Regulation
Additional information
next to '[[protein|yonT]]', the '[[protein|txpA]]' mRNA has the strongest Shine-Dalgarno region in 'B. subtilis' [PubMed|19210617]
Labs working on this gene/protein
[SW|Richard Losick], Harvard University, Cambridge, USA [http://www.mcb.harvard.edu/Losick/ Homepage]
References
Reviews
References
Original publications
proteinLength
59
geneLength
180
Gene
Coordinates
2,678,240 2,678,419
The protein
Catalyzed reaction/ biological activity
part of a type I toxin/antitoxin system (with [[protein|RatA]]) [Pubmed|27450630]
eliminates defective cells from developing biofilms [Pubmed|27450630]
The protein
Paralogous protein(s)
[[this]]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE26050 ([[gene|txpA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE26050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAATTTCACCTCCTTTCA, downstream forward: _UP4_TAGTTTCTTTTTTAAAAGCT
BKK26050 ([[gene|txpA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK26050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAATTTCACCTCCTTTCA, downstream forward: _UP4_TAGTTTCTTTTTTAAAAGCT
labs
[SW|Richard Losick], Harvard University, Cambridge, USA [http://www.mcb.harvard.edu/Losick/ Homepage]