SubtiBank SubtiBank
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Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)2025-05-12 13:09:31

description

toxic peptide

toxic peptide, eliminates defective cells from developing biofilms

locus

BSU26050

BSU_26050

ec

names

txpA

yqcR

yqdB

txpA

yqcR

outlinks

bsu

BSU26050

BSU_26050

[SW|Categories] containing this gene/protein

[SW|toxins, antitoxins and immunity against toxins], [SW|Skin element], [SW|membrane proteins]

Gene

Coordinates on the chromosome (coding sequence)

2,678,240 -> 2,678,419

The protein

[SW|Localization]

cell membrane

cell membrane (according to UniProt)

Expression and Regulation

Operon

''txpA'' [Pubmed|16166525]

Expression and Regulation

[SW|Sigma factor]

[[protein|SigA]] [Pubmed|16166525]

Expression and Regulation

Regulatory mechanism

expression is prevented by the ''[[protein|ratA]]'' antisense RNA [Pubmed|16166525]

the ''[[protein|txpA]]'' mRNA-''[[protein|RatA]]'' RNA duplex is degraded by [[rnc|RNase III]] [Pubmed|23300471]

Expression and Regulation

Additional information

next to '[[protein|yonT]]', the '[[protein|txpA]]' mRNA has the strongest Shine-Dalgarno region in 'B. subtilis' [PubMed|19210617]

Labs working on this gene/protein

[SW|Richard Losick], Harvard University, Cambridge, USA [http://www.mcb.harvard.edu/Losick/ Homepage]

References

Reviews

23300472

23300472, 31075979

References

Original publications

16166525, 19210617, 23300471

16166525, 19210617, 23300471, 27450630

proteinLength

59

geneLength

180

Gene

Coordinates

2,678,240 2,678,419

The protein

Catalyzed reaction/ biological activity

part of a type I toxin/antitoxin system (with [[protein|RatA]]) [Pubmed|27450630]

eliminates defective cells from developing biofilms [Pubmed|27450630]

The protein

Paralogous protein(s)

[[this]]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]

Biological materials

Mutant

BKE26050 ([[gene|txpA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE26050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAATTTCACCTCCTTTCA, downstream forward: _UP4_TAGTTTCTTTTTTAAAAGCT

BKK26050 ([[gene|txpA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK26050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAATTTCACCTCCTTTCA, downstream forward: _UP4_TAGTTTCTTTTTTAAAAGCT

labs

[SW|Richard Losick], Harvard University, Cambridge, USA [http://www.mcb.harvard.edu/Losick/ Homepage]