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Mon Aug 31 2015 13:56:51 GMT+0200 (CEST)2025-05-31 19:48:18

description

transcriptional repressor (ArsR family) of the sdpR-sdpI operon

transcriptional repressor ([SW|ArsR family]) of the [[gene|sdpR]]-[[gene|sdpI ]]operon

locus

BSU33790

BSU_33790

function

regulation of protection against SdpC

regulation of protection against [[protein|SdpC]]

product

transcriptional regulator (ArsR family)

transcriptional regulator ([SW|ArsR family])

ec

outlinks

bsu

BSU33790

BSU_33790

syns

yvbA

[SW|Categories] containing this gene/protein

[SW|transcription factors and their control], [SW|toxins, antitoxins and immunity against toxins]

The protein

Effectors of protein activity

[[protein|SdpI]] binds and sequesters [[protein|SdpR]] if extracellular [[protein|SdpC]] is present, this results in induction of the ''[[protein|sdpR]]-[[protein|sdpI]]'' operon [Pubmed|16469701]

[[protein|SdpI]] binds and sequesters [[protein|SdpR]] if extracellular [[protein|SdpC]] is present, this results in induction of the ''[[gene|sdpR]]-[[gene|sdpI]]'' operon [Pubmed|16469701]

The protein

[SW|Interactions]

[[protein|SdpI]]-[[protein|SdpR]] [Pubmed|16469701]

Expression and Regulation

Operon

''[[protein|sdpR]]-[[protein|sdpI]]'' [Pubmed|12817086]

Expression and Regulation

[SW|Sigma factor]

[[protein|SigA]] [Pubmed|16469701]

Expression and Regulation

Regulation

repressed during logrithmic growth ([[protein|AbrB]]) [Pubmed|16469701]

induced by extracellular [[protein|SdpC]] ([[protein|SdpR]]) [Pubmed|16469701]

Expression and Regulation

Regulatory mechanism

[[protein|AbrB]]: transcription repression [Pubmed|16469701]

[[protein|SdpR]]: transcription repression [Pubmed|16469701]

proteinLength

90

geneLength

273

Gene

Coordinates

3,467,054 3,467,326

The protein

Paralogous protein(s)

[[this]]

The protein

[SW|Domains]

[SW|HTH arsR-type domain] (aa 1-87) (according to UniProt)

The protein

Structure

[PDB|2CWE] (from Pyrococcus horikoshii, 34% identity)

The protein

additional information

information on binding sites can be found in the [http://www.prodoric2.de/detail.php?acc=MX000211 PRODORIC2 database]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]

Biological materials

Mutant

BKE33790 ([[gene|sdpR]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33790 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGCGTTTTCTCCTTTAC, downstream forward: _UP4_TTATGAAGAAAAATATAATT

BKK33790 ([[gene|sdpR]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33790 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGCGTTTTCTCCTTTAC, downstream forward: _UP4_TTATGAAGAAAAATATAATT