Fri Mar 11 2016 17:32:29 GMT+0100 (CET)2025-05-27 15:41:15
title
spoIVCB
sigK
description
[SW|RNA polymerase ][SW|sporulation]-specific [SW|sigma factor ](sigma-K) (5' part of the interrupted [[gene|sigK]] gene), with [[gene|sigKC]]
locus
BSU25760
BSU_25760
product
RNA polymerase sporulation-specific sigma factor
(sigma-K) (N-terminal half)
[SW|RNA polymerase ][SW|sporulation]-specific [SW|sigma factor](sigma-K) (5' part of the gene)
ec
names
spoIVCB
cisB
sigK
sigK
sigKN
spoIVCB
outlinks
bsu
BSU25760
BSU_25760
[SW|Categories] containing this gene/protein
[SW|transcription], [SW|sigma factors and their control], [SW|sporulation proteins], [SW|membrane proteins]
Gene
Coordinates on the chromosome (coding sequence)
2,652,993 -> 2,653,463
The protein
Protein family
sigma-70 factor family (according to Swiss-Prot)
[SW|Sigma-70 factor family] (according to UniProt)
The protein
[SW|Interactions]
[SW|SpoIVFB]-pro[[protein|SigK]] [Pubmed|23995631,23585539,19805276]
[[protein|SigK]]-([[protein|RpoB]]-[[protein|RpoC]])
Expression and Regulation
Operon
''[[protein|sigK]]'' (composed of ''[SW|spoIVCB]-[SW|spoIIIC]'') [Pubmed|2536191]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigE]] [Pubmed|15699190,2841290], [[protein|SigK]] [Pubmed|2841290]
Expression and Regulation
Regulation
expressed during sporulation in the mother cell ([[protein|SigE]], [[protein|SigK]], [[protein|GerE]], [SW|SpoIIID]) [Pubmed|15699190,2841290,10075739,7966271]
Expression and Regulation
Regulatory mechanism
[[protein|GerE]]: transcription repression [Pubmed|10075739]
[SW|SpoIIID]: transcription activation [Pubmed|7966271]
[SW|ScoC]: transcription repression [Pubmed|25983726]
Expression and Regulation
Additional information
[[protein|SigK]] is activated by processing of membrane-bound pro-[[protein|SigK]] by the [[protein|SpoIVFB]] metalloprotease [PubMed|23585539,19805276]
'spoIVCB' and '[[protein|spoIIIC]]' form a composite gene in the mother cell during sporulation by excising the intervening DNA sequence.
References
Reviews
References
Original Publications
proteinLength
156
geneLength
471
Gene
Coordinates
2,652,993 2,653,463
The protein
Paralogous protein(s)
[[this]]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE25760 ([[gene|sigK]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE25760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCGTCACCTCCACAAAAG, downstream forward: _UP4_AAAGGGGGGTGCATACACCC
BKK25760 ([[gene|sigK]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK25760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCGTCACCTCCACAAAAG, downstream forward: _UP4_AAAGGGGGGTGCATACACCC