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Tue Nov 03 2015 11:15:53 GMT+0100 (CET)2025-05-14 11:14:58

description

membrane-bound chemotaxis receptor, methyl-accepting chemotaxis protein

membrane-bound chemotaxis receptor, methyl-accepting chemotaxis protein, acts also as pH sensor, responds to decreasing pH as an attractant signal

locus

BSU31250

BSU_31250

function

control of chemotaxis

control of chemotaxis, sensing of acidic environments

ec

outlinks

bsu

BSU31250

BSU_31250

[SW|Categories] containing this gene/protein

[SW|motility and chemotaxis], [SW|membrane proteins]

The protein

[SW|Localization]

cell membrane [Pubmed|21515776], Polar (Septum) [Pubmed|16479537]

cell membrane [Pubmed|21515776], Polar (Septum) [Pubmed|16479537]

accumulates at strongly curved membrane areas generated during cell division [Pubmed|26522943]

Expression and Regulation

Operon

''[[protein|tlpA]]-[[protein|mcpA]]'' [Pubmed|8188684]

Expression and Regulation

[SW|Sigma factor]

[[protein|SigD]] [Pubmed|8188684]

Expression and Regulation

Regulatory mechanism

[[protein|AbrB]]: transcription repression [Pubmed|20817675]

Expression and Regulation

Additional information

in minimal medium, TlpA is present with 2,100 /- 890 molecules per cell [PubMed|21515776]

References

8188684, 21515776, 16479537, 20817675

proteinLength

662

geneLength

1989

Gene

Coordinates

3,208,280 3,210,268

The protein

Paralogous protein(s)

[[this]]

The protein

[SW|Domains]

[SW|Cache domain] (aa 152-228) (according to UniProt)

[SW|HAMP domain] (aa 303-355) (according to UniProt)

[SW|Methyl-accepting transducer domain] (aa 374-610) (according to UniProt)

The protein

Structure

[PDB|6S1K] (from E. coli, corresponds to aa 285 ... 552, 33% identity) [pubmed|31925330]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]

Biological materials

Mutant

BKE31250 ([[gene|tlpA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE31250 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCTTTTGAACCTTCT, downstream forward: _UP4_TAATAGGTCTAAAATACTAT

BKK31250 ([[gene|tlpA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK31250 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCTTTTGAACCTTCT, downstream forward: _UP4_TAATAGGTCTAAAATACTAT

References

Reviews

31792011

References

Original publications

8188684, 21515776, 16479537, 20817675, 26522943, 31685537, 31925330