Tue Nov 03 2015 11:15:53 GMT+0100 (CET)2025-05-14 11:14:58
description
membrane-bound chemotaxis receptor, methyl-accepting chemotaxis protein
membrane-bound chemotaxis receptor, methyl-accepting chemotaxis protein, acts also as pH sensor, responds to decreasing pH as an attractant signal
locus
BSU31250
BSU_31250
function
control of chemotaxis
control of chemotaxis, sensing of acidic environments
ec
outlinks
bsu
BSU31250
BSU_31250
[SW|Categories] containing this gene/protein
[SW|motility and chemotaxis], [SW|membrane proteins]
The protein
[SW|Localization]
cell membrane [Pubmed|21515776], Polar (Septum) [Pubmed|16479537]
cell membrane [Pubmed|21515776], Polar (Septum) [Pubmed|16479537]
accumulates at strongly curved membrane areas generated during cell division [Pubmed|26522943]
Expression and Regulation
Operon
''[[protein|tlpA]]-[[protein|mcpA]]'' [Pubmed|8188684]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigD]] [Pubmed|8188684]
Expression and Regulation
Regulatory mechanism
[[protein|AbrB]]: transcription repression [Pubmed|20817675]
Expression and Regulation
Additional information
in minimal medium, TlpA is present with 2,100 /- 890 molecules per cell [PubMed|21515776]
References
proteinLength
662
geneLength
1989
Gene
Coordinates
3,208,280 3,210,268
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Domains]
[SW|Cache domain] (aa 152-228) (according to UniProt)
[SW|HAMP domain] (aa 303-355) (according to UniProt)
[SW|Methyl-accepting transducer domain] (aa 374-610) (according to UniProt)
The protein
Structure
[PDB|6S1K] (from E. coli, corresponds to aa 285 ... 552, 33% identity) [pubmed|31925330]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE31250 ([[gene|tlpA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE31250 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCTTTTGAACCTTCT, downstream forward: _UP4_TAATAGGTCTAAAATACTAT
BKK31250 ([[gene|tlpA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK31250 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCTTTTGAACCTTCT, downstream forward: _UP4_TAATAGGTCTAAAATACTAT
References
Reviews
References
Original publications