SubtiBank SubtiBank
Version comparison:

2019-04-14 15:06:242025-05-10 19:40:32

locus

BSU18090

BSU_18090

outlinks

bsu

BSU18090

BSU_18090

Gene

Phenotypes of a mutant

essential [Pubmed|12682299]

essential [Pubmed|12682299]

upon overexpression, topoisomerase IV ([[protein|ParE]]-[[protein|ParC]]) can take over the functions of the type 1A topoisomerases [[protein|TopA]] and [[protein|TopB]] [pubmed|30957856]

The protein

Protein family

type II topoisomerase [[protein|GyrB]] family (together with [[protein|GyrB]]) (according to Swiss-Prot)

type II topoisomerase [[protein|GyrB]] family (together with [[protein|GyrB]]) (according to UniProt)

Biological materials

lacZ fusion

GP2550 ([[gene|parE]]::lacZ cat, based on [SW|pAC5]), available in [SW|Jörg Stülke]'s lab

GP2550 ([[gene|parE]]::lacZ cat, based on [SW|pAC5]), available in [SW|Jörg Stülke]'s lab [pubmed|30957856]

References

Original publications

16272394, 9539793, 16267290, 16479537, 23965305, 27120414, 9722641, 12767818, 10713132, 9334322, 8940171, 7590259, 10944214, 1330320, 12857958, 11090135, 8104339, 8227000, 30222737

16272394, 9539793, 16267290, 16479537, 23965305, 27120414, 9722641, 12767818, 10713132, 9334322, 8940171, 7590259, 10944214, 1330320, 12857958, 11090135, 8104339, 8227000, 30222737, 30957856

The protein

Catalyzed reaction/ biological activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to UniProt)