SubtiBank SubtiBank
Version comparison:

Tue Sep 06 2016 17:15:10 GMT+0200 (CEST)2025-05-14 08:38:34

locus

BSU18090

BSU_18090

outlinks

bsu

BSU18090

BSU_18090

[SW|Categories] containing this gene/protein

[SW|DNA condensation/ segregation], [SW|essential genes]

Gene

Coordinates on the chromosome (coding sequence)

1,933,477 -> 1,935,444

Gene

Phenotypes of a mutant

essential [Pubmed|12682299]

essential [Pubmed|12682299]

upon overexpression, topoisomerase IV ([[protein|ParE]]-[[protein|ParC]]) can take over the functions of the type 1A topoisomerases [[protein|TopA]] and [[protein|TopB]] [pubmed|30957856]

The protein

Protein family

type II topoisomerase family (according to Swiss-Prot)

type II topoisomerase [[protein|GyrB]] family (together with [[protein|GyrB]]) (according to UniProt)

The protein

Paralogous protein(s)

[[protein|GyrB]]

[[this]]

The protein

[SW|Interactions]

[[protein|ParC]]-[[protein|ParE]] [Pubmed|9539793]

Expression and Regulation

Operon

''[[protein|parE]]-[[protein|parC]]'' [Pubmed|16267290]

Expression and Regulation

Regulation

induced by DNA damage ([[protein|LexA]]) [Pubmed|16267290]

Expression and Regulation

Regulatory mechanism

[[protein|LexA]]: transcription repression [Pubmed|16267290]

Expression and Regulation

Additional information

term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''parE'' [Pubmed|27120414]

References

16272394, 9539793, 16267290, 16479537, 23965305, 27120414

proteinLength

655

geneLength

1968

Gene

Coordinates

1,933,477 1,935,444

The protein

Catalyzed reaction/ biological activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to UniProt)

The protein

[SW|Domains]

[SW|TOPRIM domain] (aa 423-537) [Pubmed|9722641]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]

Biological materials

lacZ fusion

GP2550 ([[gene|parE]]::lacZ cat, based on [SW|pAC5]), available in [SW|Jörg Stülke]'s lab [pubmed|30957856]

References

Reviews

16936698

References

Original publications

16272394, 9539793, 16267290, 16479537, 23965305, 27120414, 9722641, 12767818, 10713132, 9334322, 8940171, 7590259, 10944214, 1330320, 12857958, 11090135, 8104339, 8227000, 30222737, 30957856