Tue Sep 06 2016 17:15:10 GMT+0200 (CEST)2025-05-14 08:38:34
locus
BSU18090
BSU_18090
outlinks
bsu
BSU18090
BSU_18090
[SW|Categories] containing this gene/protein
[SW|DNA condensation/ segregation], [SW|essential genes]
Gene
Coordinates on the chromosome (coding sequence)
1,933,477 -> 1,935,444
Gene
Phenotypes of a mutant
essential [Pubmed|12682299]
essential [Pubmed|12682299]
upon overexpression, topoisomerase IV ([[protein|ParE]]-[[protein|ParC]]) can take over the functions of the type 1A topoisomerases [[protein|TopA]] and [[protein|TopB]] [pubmed|30957856]
The protein
Protein family
type II topoisomerase family (according to Swiss-Prot)
type II topoisomerase [[protein|GyrB]] family (together with [[protein|GyrB]]) (according to UniProt)
The protein
Paralogous protein(s)
[[protein|GyrB]]
[[this]]
The protein
[SW|Interactions]
[[protein|ParC]]-[[protein|ParE]] [Pubmed|9539793]
Expression and Regulation
Operon
''[[protein|parE]]-[[protein|parC]]'' [Pubmed|16267290]
Expression and Regulation
Regulation
induced by DNA damage ([[protein|LexA]]) [Pubmed|16267290]
Expression and Regulation
Regulatory mechanism
[[protein|LexA]]: transcription repression [Pubmed|16267290]
Expression and Regulation
Additional information
term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''parE'' [Pubmed|27120414]
References
proteinLength
655
geneLength
1968
Gene
Coordinates
1,933,477 1,935,444
The protein
Catalyzed reaction/ biological activity
ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to UniProt)
The protein
[SW|Domains]
[SW|TOPRIM domain] (aa 423-537) [Pubmed|9722641]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
lacZ fusion
GP2550 ([[gene|parE]]::lacZ cat, based on [SW|pAC5]), available in [SW|Jörg Stülke]'s lab [pubmed|30957856]
References
Reviews
References
Original publications