Tue Dec 13 2016 11:16:36 GMT+0100 (CET)2025-05-29 10:54:22
description
RNase R, required for protection against paraquat stress
RNase R, required for protection against paraquate stress
locus
BSU33610
BSU_33610
ec
outlinks
bsu
BSU33610
BSU_33610
aminos
MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVKALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNELNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKITSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHKHGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKLDDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNPKVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPLVPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEEFMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRALQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDLIVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYMLDKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNVFRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTNTPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK
[SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|RNAses], [SW|resistance against oxidative and electrophile stress]
Gene
Coordinates on the chromosome (coding sequence)
3,451,863 -> 3,454,202
The protein
Catalyzed reaction/ biological activity
3'-5'-exoribonuclease
3'-5'-exoribonuclease
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates (according to UniProt)
The protein
Protein family
ribonuclease II (RNB) family (according to Swiss-Prot)
RNR ribonuclease family (single member, according to UniProt)
Expression and Regulation
Operon
''[[protein|secG]]-[[protein|yvaK]]-[[protein|rnr]]-[[protein|smpB]]-[[protein|ssrA]]'' [Pubmed|17369301]
''[[protein|yvaK]]-[[protein|rnr]]-[[protein|smpB]]-[[protein|ssrA]]'' [Pubmed|17369301]
Expression and Regulation
[SW|Sigma factor]
''[[protein|yvaK]]'': [[protein|SigB]] [Pubmed|11544224]
Expression and Regulation
Regulation
''[[protein|yvaK]]'': induced by stress ([[protein|SigB]]) [Pubmed|11544224]
Labs working on this gene/protein
[SW|David Bechhofer], Mount Sinai School, New York, USA [http://www.mountsinai.org/Research/Centers%20Laboratories%20and%20Programs/Bechhofer%20Laboratory?citype=Physician&ciid=Bechhofer%20David%20H%201255565 Homepage]
References
Reviews
References
Original publications
proteinLength
779
geneLength
2340
Gene
Coordinates
3,451,863 3,454,202
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Domains]
[SW|S1 domain] (aa 628-708) (according to UniProt)
2 [SW|CSD domain]s (aa 73-133, aa 138-202) (according to the Interpro database)
The protein
Structure
[PDB|5XGU] (from E. coli, 40% identity) [pubmed|29036353]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-A495 (yvaJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/495 NBRP B. subtilis, Japan]
BKE33610 ([[gene|rnr]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCCATTATCCGACCTCCTG, downstream forward: _UP4_TAGCAGCTCAACCAGCAAAT
BKK33610 ([[gene|rnr]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCCATTATCCGACCTCCTG, downstream forward: _UP4_TAGCAGCTCAACCAGCAAAT
labs
[SW|David Bechhofer], Mount Sinai School, New York, USA [http://www.mountsinai.org/Research/Centers%20Laboratories%20and%20Programs/Bechhofer%20Laboratory?citype=Physician&ciid=Bechhofer%20David%20H%201255565 Homepage]