SubtiBank SubtiBank
Version comparison:

Tue Oct 13 2015 14:44:25 GMT+0200 (CEST)2025-05-11 04:33:38

locus

BSU22660

BSU_22660

outlinks

bsu

BSU22660

BSU_22660

[SW|Categories] containing this gene/protein

[SW|biosynthesis/ acquisition of amino acids]

The protein

Catalyzed reaction/ biological activity

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate CO2 H2O (according to Swiss-Prot)

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+ --> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O (according to UniProt)

Expression and Regulation

Operon

''[[protein|aroF]]-[[protein|aroB]]-[[protein|aroH]]-[[protein|trpE]]-[[protein|trpD]]-[[protein|trpC]]-[[protein|trpF]]-[[protein|trpB]]-[[protein|trpA]]-[[protein|hisC]]-[[protein|tyrA]]-[[protein|aroE]]'' (according to [http://dbtbs.hgc.jp/COG/prom/trpEDCFBA-hisC-tyrA-aroE.html DBTBS])

''[[protein|trpE]]-[[protein|trpD]]-[[protein|trpC]]-[[protein|trpF]]-[[protein|trpB]]-[[protein|trpA]]-[[protein|hisC]]-[[protein|tyrA]]-[[protein|aroE]]'' [Pubmed|3924737]

Expression and Regulation

[SW|Sigma factor]

''[[protein|trpE]]'': [[protein|SigA]] [Pubmed|6436812]

Expression and Regulation

Regulation

not expressed if tryptophan is available ([[MtrB|TRAP]]) [Pubmed|1551827]

Expression and Regulation

Regulatory mechanism

[[MtrB|TRAP]]: binding to the mRNA in the presence of tryptophan, this results in transcription termination [Pubmed|8419914]

References

14976255, 3924737, 6436812, 2422155, 8419914, 1551827, 21815947

proteinLength

250

geneLength

750

Gene

Coordinates

2,374,139 → 2,374,888

The protein

Protein family

TrpC family (single member, according to UniProt)

The protein

Paralogous protein(s)

[[this]]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]

Biological materials

Mutant

BKE22660 (Δ[[gene|trpC]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE22660 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCAAGCATAGATCTCTTC, downstream forward: _UP4_CATGCTTTGTTTAGGGAGTG

BKK22660 (Δ[[gene|trpC]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK22660 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCAAGCATAGATCTCTTC, downstream forward: _UP4_CATGCTTTGTTTAGGGAGTG

References

Reviews

12966138

References

Original publications

14976255, 3924737, 6436812, 2422155, 8419914, 1551827, 21815947