Tue Oct 13 2015 14:44:25 GMT+0200 (CEST)2025-05-11 04:33:38
locus
BSU22660
BSU_22660
outlinks
bsu
BSU22660
BSU_22660
[SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]
The protein
Catalyzed reaction/ biological activity
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate CO2 H2O (according to Swiss-Prot)
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+ --> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O (according to UniProt)
Expression and Regulation
Operon
''[[protein|aroF]]-[[protein|aroB]]-[[protein|aroH]]-[[protein|trpE]]-[[protein|trpD]]-[[protein|trpC]]-[[protein|trpF]]-[[protein|trpB]]-[[protein|trpA]]-[[protein|hisC]]-[[protein|tyrA]]-[[protein|aroE]]'' (according to [http://dbtbs.hgc.jp/COG/prom/trpEDCFBA-hisC-tyrA-aroE.html DBTBS])
''[[protein|trpE]]-[[protein|trpD]]-[[protein|trpC]]-[[protein|trpF]]-[[protein|trpB]]-[[protein|trpA]]-[[protein|hisC]]-[[protein|tyrA]]-[[protein|aroE]]'' [Pubmed|3924737]
Expression and Regulation
[SW|Sigma factor]
''[[protein|trpE]]'': [[protein|SigA]] [Pubmed|6436812]
Expression and Regulation
Regulation
not expressed if tryptophan is available ([[MtrB|TRAP]]) [Pubmed|1551827]
Expression and Regulation
Regulatory mechanism
[[MtrB|TRAP]]: binding to the mRNA in the presence of tryptophan, this results in transcription termination [Pubmed|8419914]
References
proteinLength
250
geneLength
750
Gene
Coordinates
2,374,139 → 2,374,888
The protein
Protein family
TrpC family (single member, according to UniProt)
The protein
Paralogous protein(s)
[[this]]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE22660 (Δ[[gene|trpC]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE22660 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCAAGCATAGATCTCTTC, downstream forward: _UP4_CATGCTTTGTTTAGGGAGTG
BKK22660 (Δ[[gene|trpC]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK22660 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCAAGCATAGATCTCTTC, downstream forward: _UP4_CATGCTTTGTTTAGGGAGTG
References
Reviews
References
Original publications