NfeD2, role in maintaining membrane integrity during conditions of cellular stress, confers (together with FloT) resistance to cefuroxime
function
involved in the control of membrane fluidity
product
NfeD family protein NfeD2
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.7|Membrane dynamics][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|membrane dynamics], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|SigW regulon]Gene
Coordinates on the chromosome (coding sequence)
3,182,015 -> 3,182,539
The protein
Catalyzed reaction/ biological activity
[protein|search|SigW]-dependent expression of ''[protein|search|fabF]'' and the ''[protein|search|yuaF]-[protein|search|floT]-[protein|search|yuaI]'' operon result in reduced membrane fluidity [Pubmed|21542858,22178969]Protein family
NfeD family (with [protein|search|YqeZ])Structure
[PDB|2K14][SW|Localization]
cell membrane, in focal structures [Pubmed|22753055][SW|Interactions]
[protein|search|YuaF]-[protein|search|FloT] [Pubmed|22753055]Expression and Regulation
Operon
''[protein|search|yuaF]-[protein|search|floT]-[protein|search|yuaI]'' [Pubmed|9987136][SW|Sigma factor]
[protein|search|SigW] [Pubmed|9987136]Regulation
expressed upon cell wall stress ([protein|search|SigW]) [Pubmed|9987136]References
18696230,9987136,22753055,27362352 
