SubtiBank SubtiBank
yuaF
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yuaF

NfeD2, role in maintaining membrane integrity during conditions of cellular stress, confers (together with FloT) resistance to cefuroxime
Locus
BSU_31020
Isoelectric point
4.04
Molecular weight
18.46 kDa
Protein length
174 aa Sequence Blast
Gene length
525 bp Sequence Blast
Function
involved in the control of membrane fluidity
Product
NfeD family protein NfeD2
Essential
no
Synonyms
NfeD2
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Cell envelope and cell division → Membrane dynamics
  • Lifestyles → Coping with stress → Cell envelope stress proteins (controlled by SigM, V, W, X, Y)
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    3,182,015 → 3,182,539

    The protein

    Catalyzed reaction/ biological activity

  • SigW-dependent expression of fabF and the yuaF-floT-yuaI operon result in reduced membrane fluidity PubMed

    • Protein family

  • NfeD family (with YqeZ)

    • Structure

  • 2K14 PubMed

    • Localization

  • cell membrane, in focal structures PubMed

    • Expression and Regulation

    Operons

    Genes
    yuaF-floT-yuaI
    Description
    PubMed

    Sigma factors

  • SigW: sigma factor, PubMed, in SigW regulon

    • Regulation

  • expressed upon cell wall stress (SigW) PubMed
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    Biological materials

    Mutant

  • MGNA-A212 (yuaF::erm), available at the NBRP B. subtilis, Japan
  • BKE31020 (ΔyuaF::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAACTTCCTCATCCTTTCTT, downstream forward: _UP4_TAACATAAAAGGAGGAATTT
  • BKK31020 (ΔyuaF::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAACTTCCTCATCCTTTCTT, downstream forward: _UP4_TAACATAAAAGGAGGAATTT

    • References

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