luxS [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

S-ribosylhomocysteine lyase, autoinducer-2 production protein, required for surface spreading motility (sliding) of B. subtilis natto and biofilm formation

Locus: BSU30670

Isoelectric point: 5.00

Molecular weight: 17.00 kDa

Function: methionine salvage

Product: S-ribosylhomocysteine lyase

Essential: no

E.C.: 4.4.1.21

Synonyms: ytjB

Genomic Context

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Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of methionine/ S-adenosylmethionine
• Information processing → Regulation of gene expression → Quorum sensing
• Lifestyles → Exponential and early post-exponential lifestyles → Motility and chemotaxis → Signal transduction in motility and chemotaxis → Additional chemotaxis signal transduction and regulatory proteins
• Lifestyles → Exponential and early post-exponential lifestyles → Biofilm formation
• Lifestyles → Exponential and early post-exponential lifestyles → Biofilm formation → Other proteins required for biofilm formation

Categories containing this gene/protein

• biosynthesis/ acquisition of amino acids, motility and chemotaxis, quorum sensing, biofilm formation

Gene

Coordinates on the chromosome (coding sequence): 3,137,495 -> 3,137,968

The protein

Catalyzed reaction/ biological activity

• S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine (4S)-4,5-dihydroxypentan-2,3-dione (according to Swiss-Prot)

Protein family

• luxS family (according to Swiss-Prot)

Effectors of protein activity

• subject to feedback inhibition PubMed

Structure

• 1JQW (complex with homocysteine), 1J98 PubMed

Expression and Regulation

Operon

• luxS PubMed

Additional information

• subject to feedback inhibition PubMed

Biological materials

Mutant

• 1A953 ( luxS::cat), PubMed, available at BGSC

References

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