class III heat-shock ATP-dependent protease
function
protein quality control, control of swarming motility
product
class III heat-shock ATP-dependent protease
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.4|Additional proteins involved in proteolysis][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.5|Additional chemotaxis signal transduction and regulatory proteins][SW|Categories] containing this gene/protein
[SW|proteolysis], [SW|motility and chemotaxis]This gene is a member of the following [SW|regulons]
[SW|CtsR regulon]Gene
Coordinates on the chromosome (coding sequence)
2,880,466 -> 2,882,790
Phenotypes of a mutant
presence of predifferentiated swarmer cells in liquid medium [Pubmed|25538299]The protein
Catalyzed reaction/ biological activity
Hydrolysis of proteins in presence of ATP (according to Swiss-Prot)inhibits swarming motility by preventing accumulation of SwrA in liquid medium [Pubmed|25538299]Protein family
peptidase S16 family (according to Swiss-Prot)Structure
[PDB|3M65] (N-terminal domain) [Pubmed|20600124], [PDB|3M6A] (C-terminal domain) [Pubmed|20600124], [PDB|1X37] (Ssd domain)[SW|Localization]
coincident with the nucleoid during normal growth and localized to the forespore during development [Pubmed|18689473][SW|Interactions]
homohexameric protein [Pubmed|20600124][protein|search|LonA]-[protein|search|SmiA] [Pubmed|25538299][protein|search|LonA]-[protein|search|SwrA] (degradation) [Pubmed|25538299]Expression and Regulation
Operon
''[protein|search|lonA]-[protein|search|ysxC]'' [Pubmed|7961402][SW|Sigma factor]
[protein|search|SigA] [Pubmed|7961402]Regulation
induced by heat stress ([protein|search|CtsR]) [Pubmed|9852015]Regulatory mechanism
[protein|search|CtsR]: transcription repression [Pubmed|9852015]References
Reviews
Original publications
7961403,7961402,19542270,19643080,9852015,18689473,20600124,25538299 
