product
ribosomal protein L3 (BL3)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes], [SW|universally conserved proteins]This gene is a member of the following [SW|regulons]
[SW|stringent response]Gene
Coordinates on the chromosome (coding sequence)
135,712 -> 136,341
Phenotypes of a mutant
essential [Pubmed|23002217,12682299]The protein
Catalyzed reaction/ biological activity
[protein|search|RplC] binding to the precursor 23S rRNA stimulates [protein|search|MrnC] activity [Pubmed|19154332]Protein family
[SW|ribosomal protein] L3P family (according to Swiss-Prot)[SW|Localization]
located at the peptidyl transferase center of the 50S ribosomal subunit [Pubmed|23759864][SW|Interactions]
[protein|search|YsxC]-[protein|search|RplC] [Pubmed|17981968][protein|search|RplC]-[protein|search|CshA] [Pubmed|23175651]Expression and Regulation
Operon
''[protein|search|rpsJ]-[protein|search|rplC]-[protein|search|rplD]-[protein|search|rplW]-[protein|search|rplB]-[protein|search|rpsS]-[protein|search|rplV]-[protein|search|rpsC]-[protein|search|rplP]-[protein|search|rpmC]-[protein|search|rpsQ]-[protein|search|rplN]-[protein|search|rplX]-[protein|search|rplE]-[protein|search|rpsN]-[protein|search|rpsH]-[protein|search|rplF]-[protein|search|rplR]-[protein|search|rpsE]-[protein|search|rpmD]-[protein|search|rplO]'' [Pubmed|9371452][SW|Sigma factor]
[protein|search|SigA] two promoters, about 140bp and 200bp upstream of the start codon [Pubmed|9371452]Regulation
[protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]Biological materials
two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Stülke] labReferences
17981968,9371452,19154332,19653700,11948165,8635744,23175651,23759864,23002217 
