yknY

ABC transporter (ATP-binding protein, exporter) for the export of the SdpC toxin

Locus: BSU_14360

Isoelectric point: 5.82

Molecular weight: 25.12 kDa

Protein length: 230 aa

Gene length: 693 bp

Function: resistance to SdpC toxin

Product: ABC transporter (ATP-binding protein, exporter)

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Transporters → ABC transporters → Exporters → Export of peptides
• Lifestyles → Coping with stress → Resistance against toxins/ antibiotics
• Lifestyles → Coping with stress → Cell envelope stress proteins (controlled by SigM, V, W, X, Y)
• Groups of genes → Membrane proteins

Gene

Coordinates: 1,505,416 → 1,506,108

The protein

Protein family

• ABC transporter superfamily (according to UniProt)

Paralogous protein(s)

• YtrE, FtsE, YxdL, PsdA, BceA, YvrO

Domains

• ABC transporter domain (aa 2-230) (according to UniProt)

Structure

• 1L2T (from Methanocaldococcus jannaschii, 52% identity) PubMed

Localization

• membrane associated (via YknZ) PubMed

Expression and Regulation

Operons

• Genes: yknU-yknV-yknW-yknX-yknY-yknZ
  Description: PubMed

• Genes: yknW-yknX-yknY-yknZ
  Description: PubMed

  Sigma factors

  • SigW: sigma factor, PubMed, in SigW regulon

  Regulatory mechanism

  • AbrB: repression, PubMed, in AbrB regulon

  Regulation

  • repressed during logrithmic growth (AbrB) PubMed

Biological materials

Mutant

• MGNA-B350 (yknY::erm), available at the NBRP B. subtilis, Japan
• BKE14360 (ΔyknY::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TCGCACATTAGAAAGCTGAA, downstream forward: _UP4_TCCGGACAAAGGAGTGTGGG
• BKK14360 (ΔyknY::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TCGCACATTAGAAAGCTGAA, downstream forward: _UP4_TCCGGACAAAGGAGTGTGGG

References

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