glycyl-tRNA synthetase (alpha subunit)
product
glycyl-tRNA synthetase (alpha subunit)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|T-box]Gene
Coordinates on the chromosome (coding sequence)
2,607,762 -> 2,608,649
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP glycine tRNA(Gly) = AMP diphosphate glycyl-tRNA(Gly) (according to Swiss-Prot) Protein family
class-II aminoacyl-tRNA synthetase family (according to Swiss-Prot)Structure
[PDB|1J5W] (from ''Thermotoga maritima'', 55% identity, 72% similarity)[SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[protein|search|GlyQ]-[protein|search|GlyS]Expression and Regulation
Operon
''[protein|search|glyQ]-[protein|search|glyS]'' (according to [http://dbtbs.hgc.jp/COG/prom/glyQS.html DBTBS])Regulation
induced by glycine limitation ([protein|search|T-box]) [Pubmed|19258532]Regulatory mechanism
[protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|19258532]Additional information
belongs to the 100 [[most abundant proteins]] [PubMed|15378759]References
15890195,15663928,19258532,15292140,16741230,12923262,15378759,24954903,26229106,23589841 
