ykzW [Sun Dec 18 2016 20:04:57 GMT+0100 (CET)]

small regulatory RNA controlling AhrC expression, regulatory peptide

Locus: BSU14629

Isoelectric point: 4.00

Molecular weight: 4.00 kDa

Function: control of arginine metabolism and glycolysis

Product: small regulatory RNA, regulatory peptide

Essential: no

Synonyms: ykzW, sr1

Genomic Context

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Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of arginine
• Metabolism → Amino acid/ nitrogen metabolism → Utilization of amino acids → Utilization of arginine/ ornithine
• Groups of genes → NcRNA → Regulatory RNAs

Categories containing this gene/protein

• biosynthesis/ acquisition of amino acids, utilization of amino acids, ncRNA

This gene is a member of the following regulons

• CcpN regulon

Gene

Coordinates on the chromosome (coding sequence): 1,534,120 -> 1,534,239

The peptide

Catalyzed reaction/ biological activity:

• the peptide controls the stability of the cggR-gapA mRNA PubMed

Protein family:

• the peptide is conserved in bacilli

Interactions:

• GapA-YkzW PubMed

The RNA

Catalyzed reaction/ biological activity

• hybridizes to ahrC mRNA and inhibits AhrC translation PubMed

Interactions

• ahrC mRNA-ykzW RNA PubMed

Additional information

• Information on the structure of the RNA can be found in PubMed

Expression and Regulation

Operon

• sr1 PubMed

Sigma factor

• SigA PubMed

Regulation

• Repressed in the presence of glucose by CcpN PubMed

Regulatory mechanism

• transcription repression PubMed

Biological materials

Mutant

• 168 ykzW::cat, available in Sabine Brantl's lab
• GP2210 (ykzW::cat), available in Jörg Stülke's lab
• GP2215 (ykzW::aphA3), available in Jörg Stülke's lab
• GP2216 (ykzW::phleo), available in Jörg Stülke's lab

Labs working on this gene/protein

• Sabine Brantl, Bacterial Genetics, Friedrich-Schiller-University of Jena, Germany homepage

References

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