sr1 [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

small regulatory RNA controlling AhrC expression, regulatory peptide

locus: BSU14629

pI: 4.00

mw: 4.00 kDa

function: control of arginine metabolism and glycolysis

product: small regulatory RNA, regulatory peptide

essential: no

synonyms: ykzW

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine]
• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.4|Utilization of arginine/ ornithine]
• [category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA] → [category|SW 6.9.5|Regulatory RNAs]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids], [SW|utilization of amino acids], [SW|ncRNA]

This gene is a member of the following [SW|regulons]

• [SW|CcpN regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,534,120 -> 1,534,239

The protein

Catalyzed reaction/ biological activity

• hybridizes to ''[protein|search|ahrC]'' mRNA and inhibits [protein|search|AhrC] translation. [Pubmed|17020585]

= Extended information on the RNA=

Protein family

• the peptide is conserved in bacilli

[SW|Interactions]

• [protein|search|GapA]-[protein|search|YkzW] [Pubmed|20444087]

Additional information

• Information on the structure of the RNA can be found in [Pubmed|17020585]
• =The peptide=

= Basic information/ Evolution =

• '''Catalyzed reaction/ biological activity:''' the peptide controls the stability of the ''[protein|search|cggR]-[protein|search|gapA]'' mRNA [Pubmed|20444087]
• '''Protein family:''' the peptide is conserved in bacilli
• '''Paralogous protein(s):

= Extended information on the protein =

• '''Kinetic information:
• '''Domains:
• '''Modification:
• '''Cofactor(s):
• '''Effectors of protein activity:
• '''[SW|Interactions]:
• [protein|search|GapA]-[protein|search|YkzW] [Pubmed|20444087]
• '''[SW|Localization]:

= Database entries =

• '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU14629&redirect=T BSU14629]
• '''Structure:
• '''UniProt:''' [http://www.uniprot.org/uniprot/C0H410 C0H410]
• '''KEGG entry:
• '''E.C. number:

Expression and Regulation

Operon

• sr1 [Pubmed|16164558]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|16164558]

Regulation

• Repressed in the presence of glucose by [protein|search|CcpN] [Pubmed|16164558]

Regulatory mechanism

• transcription repression [Pubmed|16164558]

Biological materials

Mutant

• 168 sr1::cat, available in [SW|Brantl] lab

Labs working on this gene/protein

• [SW|Sabine Brantl], Bacterial Genetics, Friedrich-Schiller-University of Jena, Germany [http://www.uni-jena.de/AG_Bakteriengenetik_(_Doz__Dr__Sabine_Brantl_).html homepage]

References

• 16164558,17020585,17576690,20444087