fabHB [Mon Aug 31 2015 13:53:27 GMT+0200 (CEST)]

beta-ketoacyl-acyl carrier protein synthase III

locus: BSU10170

pI: 5.68

mw: 35.00 kDa

function: fatty acid biosynthesis

product: beta-ketoacyl-acyl carrier protein synthase III

essential: no

ec: 2.3.1.180

synonyms: yhfB

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids]

syns: yhfB

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of lipids]

This gene is a member of the following [SW|regulons]

• [SW|FapR regulon]

The protein

Catalyzed reaction/ biological activity

• Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacyl-[acyl-carrier-protein] + CoA + CO₂ (according to Swiss-Prot)

Protein family

• fabH family (according to Swiss-Prot)

Paralogous protein(s)

• [SW|FabHA], one of the two proteins has to be present for viability [Pubmed|17114254]

Structure

• [PDB|1EBL] (FabH from ''E. coli'') [Pubmed|10673437]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Additional information

• affinity for butyryl-CoA, but prefers acetyl-CoA in fatty acid biosynthesis [Pubmed|19820084]

Expression and Regulation

Operon

• ''fabHB'' [Pubmed|12737802]

Regulation

• induced if the cells experience a lack of malonyl-CoA ([protein|search|FapR]) [Pubmed|12737802]
• induced upon fatty acid biosynthesis inhibition [Pubmed|21383089]

Regulatory mechanism

• [protein|search|FapR]: transcription repression [Pubmed|12737802]

References

Reviews

• 15952903,17919287

Original Publications

• 12737802,17114254,10629181,10673437,19820084,21383089,25196128