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fabHB [Mon Aug 31 2015 13:53:27 GMT+0200 (CEST)]
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fabHB [Mon Aug 31 2015 13:53:27 GMT+0200 (CEST)]

beta-ketoacyl-acyl carrier protein synthase III
Locus
BSU10170
Isoelectric point
5.68
Molecular weight
35.00 kDa
Function
fatty acid biosynthesis
Product
beta-ketoacyl-acyl carrier protein synthase III
Essential
no
E.C.
2.3.1.180
Synonyms
yhfB

Genomic Context

      
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Categories containing this gene/protein

Syns
yhfB

Categories containing this gene/protein

This gene is a member of the following regulons

The protein

Catalyzed reaction/ biological activity

  • Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacyl-[acyl-carrier-protein] + CoA + CO2 (according to Swiss-Prot)
  • Protein family

  • fabH family (according to Swiss-Prot)
  • Paralogous protein(s)

  • FabHA, one of the two proteins has to be present for viability PubMed
  • Structure

  • 1EBL (FabH from E. coli) PubMed
  • Localization

  • cytoplasm (according to Swiss-Prot)
  • Additional information

  • affinity for butyryl-CoA, but prefers acetyl-CoA in fatty acid biosynthesis PubMed
  • Expression and Regulation

    Operon

  • fabHB PubMed
  • Regulation

  • induced if the cells experience a lack of malonyl-CoA (FapR) PubMed
  • induced upon fatty acid biosynthesis inhibition PubMed
  • Regulatory mechanism

  • FapR: transcription repression PubMed
  • References

    Reviews

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    Original Publications

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