fabHB [Mon Aug 31 2015 13:53:27 GMT+0200 (CEST)]

beta-ketoacyl-acyl carrier protein synthase III

Locus: BSU10170

Isoelectric point: 5.68

Molecular weight: 35.00 kDa

Function: fatty acid biosynthesis

Product: beta-ketoacyl-acyl carrier protein synthase III

Essential: no

E.C.: 2.3.1.180

Synonyms: yhfB

Genomic Context

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Categories containing this gene/protein

• Metabolism → Lipid metabolism → Biosynthesis of lipids → Biosynthesis of fatty acids

Syns: yhfB

Categories containing this gene/protein

• biosynthesis of lipids

This gene is a member of the following regulons

• FapR regulon

The protein

Catalyzed reaction/ biological activity

• Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacyl-[acyl-carrier-protein] + CoA + CO₂ (according to Swiss-Prot)

Protein family

• fabH family (according to Swiss-Prot)

Paralogous protein(s)

• FabHA, one of the two proteins has to be present for viability PubMed

Structure

• 1EBL (FabH from E. coli) PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Additional information

• affinity for butyryl-CoA, but prefers acetyl-CoA in fatty acid biosynthesis PubMed

Expression and Regulation

Operon

• fabHB PubMed

Regulation

• induced if the cells experience a lack of malonyl-CoA (FapR) PubMed
• induced upon fatty acid biosynthesis inhibition PubMed

Regulatory mechanism

• FapR: transcription repression PubMed

References

Reviews

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Original Publications

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