plsC [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

acyl-ACP:1-acylglycerolphosphate acyltransferase

locus: BSU09540

pI: 9.98

mw: 21.00 kDa

function: biosynthesis of phospholipids

product: acyl-ACP:1-acylglycerolphosphate acyltransferase

essential: yes

ec: 2.3.1.51

synonyms: yhdO

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of lipids], [SW|general stress proteins (controlled by SigB)], [SW|essential genes], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|FapR regulon], [SW|SigB regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,031,395 -> 1,031,994

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

[SW|Localization]

• cell membrane at the septum [Pubmed|15743965]

Expression and Regulation

Operon

• ''[protein|search|yhdN]-[protein|search|plsC]'' [Pubmed|10220166]

[SW|Sigma factor]

• [protein|search|SigB] [Pubmed|10220166,15805528]

Regulation

• induced by stress ([protein|search|SigB]) [Pubmed|10220166,15805528]
• induced upon malonyl-CoA limitation ([protein|search|FapR]) [Pubmed|12737802]

Regulatory mechanism

• [protein|search|FapR]: transcription repression [Pubmed|12737802]

References

• 12737802,17557823,24574048,15743965