kduD [2017-05-17 12:30:34]

2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

locus: BSU22140

pI: 6.50

mw: 27.04 kDa

protein length: 254 aa

gene length: 762 bp

function: utilization of galacturonic acid

essential: no

ec: 1.1.1.125

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.15|Utilization of hexuronate]

Gene

Coordinates: 2,326,683 → 2,327,447

The protein

Catalyzed reaction/ biological activity

• 2-deoxy-D-gluconate + NAD⁺ = 3-dehydro-2-deoxy-D-gluconate + NADH (according to Swiss-Prot)

Protein family

• phosphopentomutase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|B6FF689E65906186F3576B378650D713DB84EDDA|YcdF], [protein|3161519994609DA9360ED6E073E4A4C8C6210EFB|YdaD]

Structure

• [PDB|4HP8] (from Agrobacterium tumefaciens, 54% identity)

Expression and Regulation

Operons

• genes: [gene|CFAEF60AD73F18C8DB5EF042210602B149D51152|kduI]-[gene|FBBDE1E058223D5E8CEB07CAA50940A329C809E4|kduD]
  description: [Pubmed|17322190]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17322190], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|891A32A19D1353BA566FF121BBCA7B986D31D129|KdgR]: repression, [Pubmed|17322190], in [regulon|891A32A19D1353BA566FF121BBCA7B986D31D129|KdgR regulon]
  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|17322190], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]

  regulation

  • induced by galacturonate ([protein|search|KdgR]) [Pubmed|17322190]

References

• 17322190