SubtiBank SubtiBank
polC [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

polC [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

DNA polymerase III (alpha subunit), part of the replisome
locus
BSU16580
pI
5.14
mw
162.00 kDa
function
DNA replication
product
DNA polymerase III (alpha subunit)
essential
yes
ec
2.7.7.7
synonyms
mutI, dnaF, dnaP
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
    • syns
    mutI, dnaF, dnaP

    [SW|Categories] containing this gene/protein

  • [SW|DNA replication], [SW|essential genes]

    • Gene

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)
  • required for bacteriophage SPP1 replication [Pubmed|23268446]

    • Protein family

  • PolC subfamily (according to Swiss-Prot)

    • Structure

  • [PDB|3F2B] (from ''Geobacillus kaustophilus'', 71% identity) [Pubmed|19106298]

    • [SW|Localization]

  • forms foci [Pubmed|21958350]
  • cytoplasm (according to Swiss-Prot)

    • [SW|Interactions]

  • part of the [SW|replisome]: [protein|search|PolC]-[protein|search|HolA]-[protein|search|HolB]-[protein|search|DnaX]-[protein|search|DnaN]-[protein|search|DnaG]-[protein|search|DnaC]-[protein|search|DnaI]-[protein|search|DnaD]-[protein|search|SsbA]-[protein|search|DnaE]-[protein|search|PriA]-[protein|search|DnaB] [Pubmed|20122408]
  • [protein|search|DnaE]-[protein|search|PolC] [Pubmed|23563155]

    • References

    Reviews

  • 19106294

    • Original publications

  • 15186423,20122408,11721055,23563155,23268446,21740522,21958350,24062730,24106089,19106298