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polC [Fri Dec 23 2016 15:42:37 GMT+0100 (CET)]
DNA polymerase III (alpha subunit), part of the replisome
product
DNA polymerase III (alpha subunit)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|DNA replication], [SW|essential genes]Gene
Coordinates on the chromosome (coding sequence)
1,727,133 -> 1,731,446
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
Deoxynucleoside triphosphate DNA(n) = diphosphate DNA(n1) (according to Swiss-Prot)required for bacteriophage SPP1 replication [Pubmed|23268446] Protein family
PolC subfamily (according to Swiss-Prot)Structure
[PDB|3F2B] (from ''Geobacillus kaustophilus'', 71% identity) [Pubmed|19106298][SW|Localization]
forms foci [Pubmed|21958350]cytoplasm (according to Swiss-Prot)[SW|Interactions]
part of the [SW|replisome]: [protein|search|PolC]-[protein|search|HolA]-[protein|search|HolB]-[protein|search|DnaX]-[protein|search|DnaN]-[protein|search|DnaG]-[protein|search|DnaC]-[protein|search|DnaI]-[protein|search|DnaD]-[protein|search|SsbA]-[protein|search|DnaE]-[protein|search|PriA]-[protein|search|DnaB] [Pubmed|20122408][protein|search|DnaE]-[protein|search|PolC] [Pubmed|23563155]Expression and Regulation
Additional information
there are about 60 molecules of PolC present per cell [Pubmed|28002733]References
Reviews
Original publications
15186423,20122408,11721055,23563155,23268446,21740522,21958350,24062730,24106089,19106298,28002733