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polC [Fri Dec 23 2016 15:42:37 GMT+0100 (CET)]
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polC [Fri Dec 23 2016 15:42:37 GMT+0100 (CET)]

DNA polymerase III (alpha subunit), part of the replisome
locus
BSU16580
pI
5.00
mw
162.00 kDa
function
DNA replication
product
DNA polymerase III (alpha subunit)
essential
yes
ec
2.7.7.7
synonyms
mutI, dnaF, dnaP

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|DNA replication], [SW|essential genes]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,727,133 -> 1,731,446

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • Deoxynucleoside triphosphate DNA(n) = diphosphate DNA(n1) (according to Swiss-Prot)
  • required for bacteriophage SPP1 replication [Pubmed|23268446]
  • Protein family

  • PolC subfamily (according to Swiss-Prot)
  • Structure

  • [PDB|3F2B] (from ''Geobacillus kaustophilus'', 71% identity) [Pubmed|19106298]
  • [SW|Localization]

  • forms foci [Pubmed|21958350]
  • cytoplasm (according to Swiss-Prot)
  • [SW|Interactions]

  • part of the [SW|replisome]: [protein|search|PolC]-[protein|search|HolA]-[protein|search|HolB]-[protein|search|DnaX]-[protein|search|DnaN]-[protein|search|DnaG]-[protein|search|DnaC]-[protein|search|DnaI]-[protein|search|DnaD]-[protein|search|SsbA]-[protein|search|DnaE]-[protein|search|PriA]-[protein|search|DnaB] [Pubmed|20122408]
  • [protein|search|DnaE]-[protein|search|PolC] [Pubmed|23563155]
  • Expression and Regulation

    Additional information

  • there are about 60 molecules of PolC present per cell [Pubmed|28002733]
  • References

    Reviews

  • 19106294
  • Original publications

  • 15186423,20122408,11721055,23563155,23268446,21740522,21958350,24062730,24106089,19106298,28002733