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polC [2017-06-05 16:00:26]
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polC [2017-06-05 16:00:26]

DNA polymerase III (alpha subunit), part of the replisome
locus
BSU16580
pI
5.14
mw
162.42 kDa
protein length
1437 aa Sequence Blast
gene length
4311 bp Sequence Blast
function
DNA replication
product
DNA polymerase III (alpha subunit)
essential
yes
ec
2.7.7.7
synonyms
mutI, dnaF, dnaP

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    1,727,133 → 1,731,446

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)
  • required for bacteriophage SPP1 replication [Pubmed|23268446]
  • Protein family

  • PolC subfamily (according to Swiss-Prot)
  • Structure

  • [PDB|3F2B] (from ''Geobacillus kaustophilus'', 71% identity) [Pubmed|19106298]
  • [SW|Localization]

  • forms foci [Pubmed|21958350]
  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    genes
    [gene|58CDF08A8F05C0BC25EB6E400316F85FD0F307E5|ispC]-[gene|CB50289535EA537F63BADD459BD11AA7759A6658|rasP]-[gene|848570563D3C92A8E1E6AB4DA530388D8AE94E75|proS]-[gene|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC]
    description
    [Pubmed|22383849]
    view in new tab

    genes
    [gene|4A637EB9B400D30E5C6246D1E0EB5E6A30F38A16|uppS]-[gene|7E7F6BBA03C443A5AFA05A6D9352FEF1212A5AF6|cdsA]-[gene|58CDF08A8F05C0BC25EB6E400316F85FD0F307E5|ispC]-[gene|CB50289535EA537F63BADD459BD11AA7759A6658|rasP]-[gene|848570563D3C92A8E1E6AB4DA530388D8AE94E75|proS]-[gene|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC]
    description
    [Pubmed|22383849]
    view in new tab

    References

    Reviews

  • 19106294,28073967
  • Original publications

  • 15186423,20122408,11721055,23563155,23268446,21740522,21958350,24062730,24106089,19106298,28002733