glycine betaine ABC transporter (ATP-binding protein)
function
compatible solute transport
product
glycine betaine ABC transporter (ATP-binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.4|Uptake of compatible solutes for osmoprotection][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|coping with hyper-osmotic stress], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|RemA regulon]Gene
Coordinates on the chromosome (coding sequence)
321,013 -> 322,269
The protein
Catalyzed reaction/ biological activity
uptake of glycine betaineuptake of dimethylglycine [Pubmed|24561588]Protein family
[SW|ABC transporter] domain (according to Swiss-Prot)[SW|Domains]
2 [SW|CBS domain]s (284-340, 344-403)[SW|Localization]
associated to the membrane (via [SW|OpuAB]) [Pubmed|10092453][SW|Interactions]
[SW|OpuAA]-[SW|OpuAB]-[SW|OpuAC] [Pubmed|10092453]Expression and Regulation
Operon
''[SW|opuAA]-[SW|opuAB]-[SW|opuAC]'' [Pubmed|22383849][SW|Sigma factor]
[protein|search|SigA] [Pubmed|23175650]Regulation
induced by osmotic stress [Pubmed|23175650]repressed by intracellular glycine betaine [Pubmed|23175650]Regulatory mechanism
[protein|search|RemA]: transcription activation [Pubmed|23646920]Biological materials
Expression vector
pGP2924 (N-terminal His-tag, purification from ''E. coli'', in [SW|pWH844]), available in [SW|Jörg Stülke]'s labLabs working on this gene/protein
[SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]References
7622480,10092453,16645306,14623183,18321243,16225868,21296969,22383849,23175650,23646920,24561588 
