sul [Wed Feb 15 2017 18:05:47 GMT+0100 (CET)]

dihydropteroate synthase

locus: BSU00770

pI: 5.00

mw: 30.00 kDa

function: biosynthesis of folate

product: dihydropteroate synthase

essential: yes

ec: 2.5.1.15

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

Gene

Coordinates on the chromosome (coding sequence): 85,737 -> 86,594

Phenotypes of a mutant

• essential [Pubmed|28189581]

The protein

Catalyzed reaction/ biological activity

• (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate 4-aminobenzoate = diphosphate dihydropteroate (according to Swiss-Prot)

Protein family

• pterin-binding domain (according to Swiss-Prot)

Structure

• [PDB|1AJZ] (from ''Escherichia coli'', 43% identity, 61% similarity) [Pubmed|9187658]

Expression and Regulation

Operon

• ''[protein|search|pabB]-[protein|search|pabA]-[protein|search|pabC]-[protein|search|sul]-[protein|search|folB]-[protein|search|folK]-[protein|search|yazB]-[protein|search|yacF]-[protein|search|lysS]'' [Pubmed|9084182]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|9084182]

References

• 9084182,28189581