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sul
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sul

dihydropteroate synthase
Locus
BSU_00770
Isoelectric point
5.36
Molecular weight
30.85 kDa
Protein length
285 aa Sequence Blast
Gene length
858 bp Sequence Blast
Function
biosynthesis of folate
Product
dihydropteroate synthase
Essential
yes
E.C.
2.5.1.15
Synonyms

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
85,737 → 86,594

Phenotypes of a mutant

  • essential PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate --> diphosphate + dihydropteroate (according to UniProt)
  • Protein family

  • DHPS family (single member, according to UniProt)
  • Domains

  • Pterin-binding domain (aa 25-271) (according to UniProt)
  • Structure

  • 1AJZ (from Escherichia coli, 43% identity, 61% similarity) PubMed
  • Localization

  • cytoplasm (according to UniProt)
  • Expression and Regulation

    Operons

    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • Regulation

  • translation repressed by tryptophan (MtrB) PubMed
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    References

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