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sul
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sul

dihydropteroate synthase
Locus
BSU_00770
Isoelectric point
5.36
Molecular weight
30.85 kDa
Protein length
285 aa Sequence Blast
Gene length
858 bp Sequence Blast
Function
biosynthesis of folate
Product
dihydropteroate synthase
Essential
yes
E.C.
2.5.1.15
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of folate
  • Groups of genes → Essential genes

    • Gene

    Coordinates
    85,737 → 86,594

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate --> diphosphate + dihydropteroate (according to UniProt)

    • Protein family

  • DHPS family (single member, according to UniProt)

    • Domains

  • Pterin-binding domain (aa 25-271) (according to UniProt)

    • Structure

  • 1AJZ (from Escherichia coli, 43% identity, 61% similarity) PubMed

    • Localization

  • cytoplasm (according to UniProt)

    • Expression and Regulation

    Operons

    Genes
    pabB-pabA-pabC-sul-folB-folK-yazB-yacF-lysS
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulation

  • translation repressed by tryptophan (MtrB) PubMed
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    References

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