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bacG [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]
short chain reductase involved in bacilysin synthesis
function
biosynthesis of the antibiotic bacilysin
product
short chain reductase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds][SW|Categories] containing this gene/protein
[SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]This gene is a member of the following [SW|regulons]
[SW|CodY regulon]Gene
Coordinates on the chromosome (coding sequence)
3,867,493 -> 3,868,272
The protein
Catalyzed reaction/ biological activity
BacG catalyzes the conjugate addition of hydride at the C4 olefinic terminus using NADH to yield the cyclohexenol- containing tetrahydro-4-hydroxyphenylpyruvate [Pubmed|20052993]stereoselective reduction of dihydro-hydroxyphenylpyruvate (H2HPP) to tetrahydro-hydroxyphenylpyruvate (H4HPP), NADPH-dependent reductase that facilitates the conjugate addition of a hydride at the C(4) olefin terminus of H2HPP [Pubmed|23519407]Protein family
short-chain dehydrogenases/reductases (SDR) family (according to Swiss-Prot)[SW|Cofactors]
NADPH [Pubmed|23519407]Structure
[PDB|3U49] [Pubmed|23519407]Expression and Regulation
Operon
''bacG'' [Pubmed|12372825]Regulation
repressed by casamino acids [Pubmed|12107147]Regulatory mechanism
[protein|search|CodY]: transcription repression [Pubmed|12372825]References
12372825,12107147,20052993,21948839,23519407 
