fadM [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

fatty acid degradation, similar to proline dehydrogenase

locus: BSU32850

pI: 9.38

mw: 34.00 kDa

function: fatty acid degradation

product: unknown

essential: no

synonyms: yusM

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.5|Newly identified sporulation proteins (based on transcription profiling)]

[SW|Categories] containing this gene/protein

• [SW|utilization of lipids], [SW|sporulation proteins]

This gene is a member of the following [SW|regulons]

• [SW|FadR regulon], [SW|SdpR regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,372,740 -> 3,373,648

The protein

Catalyzed reaction/ biological activity

• L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor (according to Swiss-Prot)

Protein family

• proline dehydrogenase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|PutB]

Expression and Regulation

Operon

• ''[protein|search|fadM]-[protein|search|fadN]-[protein|search|fadA]-[protein|search|fadE]'' [Pubmed|17189250]

Regulation

• ''[protein|search|fadM]'': induced by long-chain fatty acids ([protein|search|FadR]) [Pubmed|17189250]

Regulatory mechanism

• [protein|search|FadR]: transcription repression [Pubmed|17189250]
• [protein|search|SdpR]: transcription activation [Pubmed|12817086]

References

• 17189250,12817086