transcription regulator of iron homoeostasis, sensor of Fe sufficiency
function
regulation of iron homoeostasis
product
transcriptional repressor Fur family
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][SW|Categories] containing this gene/protein
[SW|acquisition of iron], [SW|iron metabolism], [SW|transcription factors and their control], [SW|glutamate metabolism]This gene is a member of the following [SW|regulons]
[SW|PerR regulon]Gene
Coordinates on the chromosome (coding sequence)
2,449,841 -> 2,450,290
Phenotypes of a mutant
no growth with glucose and ammonium as single sources of carbon and nitrogen, respectively (due to [protein|search|FsrA]-mediated repression of the ''[protein|search|gltA]-[protein|search|gltB]'' operon) [Pubmed|22389480]poor frowth on lactate as single carbon source (due to overexpression of [SW|FsrA]-mediated repression of the ''[protein|search|lutA]-[protein|search|lutB]-[protein|search|lutC]'' operon, can be suppressed by inactivation of ''[protein|search|fsrA]'' or ''[protein|search|fbpB]'') [Pubmed|22427629]transcription profile of a ''[protein|search|fur]'' mutant strain: [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27416 GEO] [Pubmed|22389480]The protein
Protein family
[SW|Fur family]Paralogous protein(s)
[protein|search|PerR], [protein|search|Zur][SW|Cofactors]
Fe(II)Effectors of protein activity
DNA binding activity (repression) is triggered by binding of Fe(II) [Pubmed|23057863][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''fur'' [Pubmed|12029044][SW|Sigma factor]
[protein|search|SigA] [Pubmed|12029044]Regulation
repressed in the absence of hydrogen peroxide ([protein|search|PerR]) [Pubmed|12029044]Regulatory mechanism
[protein|search|PerR]: transcription repression [Pubmed|12029044]Biological materials
Mutant
HB6543 (aphA3), available in the [SW|John Helmann] lab; also available in the [SW|Stülke] lab GP879 (''fur::mls'') and GP868 (''fur::mls'', ''perR::spc'')1A910 ( ''fur''::''kan''), [Pubmed|12029044], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A910&Search=1A910 BGSC]Labs working on this gene/protein
[SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]References
Reviews
15802251,25209494,25160631 The [SW|Fur regulon]
12374814,12354229,22389480,21873409 Other original publications
18487332,14563870,18697947,10400588,11790741,12207695,9701813,12029044,22427629,17725565,17012385,12950915,19508286,16672620,23057863,25486128 
