yfkM [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

glyoxalase III-like enzyme, general stress protein, survival of salt, paraquat and ethanol stresses

locus: BSU07850

pI: 4.72

mw: 18.00 kDa

function: detoxification of methylglyoxal

product: glyoxalase III-like enzyme

essential: no

synonyms

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

[SW|Categories] containing this gene/protein

• [SW|general stress proteins (controlled by SigB)], [SW|resistance against oxidative and electrophile stress]

This gene is a member of the following [SW|regulons]

• [SW|Fur regulon], [SW|SigB regulon]

Gene

Coordinates on the chromosome (coding sequence): 859,745 -> 860,263

The protein

Catalyzed reaction/ biological activity

• methylglyoxal --> D-lactate [Pubmed|24330391]

Protein family

• PfpI endopeptidase domain (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|YraA]

Expression and Regulation

Operon

• ''yfkM'' [Pubmed|12354229]

[SW|Sigma factor]

• [protein|search|SigB] [Pubmed|15805528]

Regulation

• induced by stress ([protein|search|SigB]) [Pubmed|15805528]
• induced upon iron starvation ([protein|search|Fur]) [Pubmed|12354229]

Regulatory mechanism

• [protein|search|Fur]: transcription repression [Pubmed|12354229]

References

• 10220166,24330391,12354229,15805528,22582280