scoC [Thu Aug 25 2016 17:06:39 GMT+0200 (CEST)]

transcriptional repressor of genes expressed in the transition phase

Locus: BSU09990

Isoelectric point: 5.00

Molecular weight: 23.00 kDa

Function: transition state regulator

Product: transcriptional repressor (MarR family)

Essential: no

Synonyms: hpr, catA

Genomic Context

Loading

Categories containing this gene/protein

• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other
• Information processing → Regulation of gene expression → Transition state regulators
• Groups of genes → Phosphoproteins → Phosphorylation on an Arg residue

Categories containing this gene/protein

• transcription factors and their control, transition state regulators, phosphoproteins

This gene is a member of the following regulons

• AbrB regulon, CodY regulon, SalA regulon, SenS regulon

Gene

Coordinates on the chromosome (coding sequence): 1,073,106 -> 1,073,717

The protein

Modification

• phosphorylated on Arg-3 PubMed

Effectors of protein activity

• activity is inhibited in an unknown way by PrkA (possibly phosphorylation) PubMed

Structure

• 2FXA

Interactions

• SinR-ScoC

Expression and Regulation

Operon

• scoC PubMed

Sigma factor

• SigA PubMed

Regulation

• expressed upon transition into the stationary phase (AbrB) PubMed

Regulatory mechanism

• AbrB: transcription activation PubMed
• SenS: positive regulation PubMed
• SalA: negative regulation PubMed
• CodY: negative regulation PubMed

Biological materials

Mutant

• Strain OM213 of Ogura MA, et al PubMed, genotype trpC2 scoC::pMutin-scoC leuC7, available as BGSC 1A918
• 1A918 ( scoC::erm), PubMed, available at BGSC

Expression vector

• for expression, purification in E. coli with N-terminal His-tag, pRSETA available in Gerth lab

References

Loading