SubtiBank SubtiBank
dnaG
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dnaG

DNA primase, part of the replisome
Locus
BSU_25210
Isoelectric point
6.71
Molecular weight
68.62 kDa
Protein length
603 aa Sequence Blast
Gene length
1812 bp Sequence Blast
Product
DNA primase
Essential
yes
E.C.
2.7.7.-
Synonyms

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
2,601,528 → 2,603,339

Phenotypes of a mutant

  • essential PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • required for bacteriophage SPP1 replication PubMed
  • Protein family

  • DNA primase family (single member, according to UniProt)
  • Domains

  • TOPRIM domain (aa 262-343) PubMed
  • Effectors of protein activity

  • the enzymatic activity is inhibited by (p)ppGpp during the 'stringent response' PubMed
  • DnaG primase activity is stimulates by DnaC PubMed
  • Structure

  • 1D0Q (zinc binding domain, Geobacillus stearothermophilus)
  • 1Z8S (DnaB binding domain, AA 452-597, Geobacillus stearothermophilus)
  • 4M4W (the DnaC-DnaI-DnaG complex) PubMed
  • Localization

  • Cytoplasm (Homogeneous) PubMed
  • Expression and Regulation

    Operons

    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigH: sigma factor, PubMed, in SigH regulon
  • Regulatory mechanism

  • Spo0A: repression, PubMed, in Spo0A regulon
  • Regulation

  • enzymatic activity is inhibited by (p)ppGpp during the 'stringent response
  • Additional information

  • An antisense RNA is predicted for sigA PubMed
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    References

    Reviews

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    Original publications

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