dacF [Tue Feb 23 2016 19:11:04 GMT+0100 (CET)]

penicillin-binding protein I, D-alanyl-D-alanine carboxypeptidase

locus: BSU23480

pI: 9.00

mw: 43.00 kDa

function: carboxypeptidase

product: penicillin-binding protein I,
D-alanyl-D-alanine carboxypeptidase

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.7|Penicillin-binding proteins]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
• [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

[SW|Categories] containing this gene/protein

• [SW|cell wall synthesis], [SW|sporulation proteins], [SW|penicillin-binding proteins]

This gene is a member of the following [SW|regulons]

• [SW|SigF regulon], [SW|SigG regulon], [SW|AbrB regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,445,094 -> 2,446,263

The protein

Catalyzed reaction/ biological activity

• modifies degree of cross-linking of glycan strands in peptidoglycan

Protein family

• peptidase S11 family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|DacA]

Expression and Regulation

Operon

• ''[protein|search|dacF]-[SW|spoIIAA]-[SW|spoIIAB]-[protein|search|sigF]'' [Pubmed|22383849]

[SW|Sigma factor]

• [protein|search|SigF] [Pubmed|15699190], [protein|search|SigG]

Regulation

• repressed by casamino acids [Pubmed|12107147]
• expressed during sporulation in the forespore [Pubmed|15758244]

Regulatory mechanism

• [protein|search|AbrB]: transcription repression [Pubmed|20817675]

References

• 16497325,8936302,9864321,12107147,20817675,22123250