SubtiBank SubtiBank
ysbB [2017-8-11 16:0:3]
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ysbB [2017-8-11 16:0:3]

antiholin-like protein
locus
BSU28900
pI
9.81
mw
24.25 kDa
protein length
231 aa Sequence Blast
gene length
693 bp Sequence Blast
function
unknown
product
antiholin-like protein
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.4|Transporter for organic acids]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    2,954,492 → 2,955,187

    Phenotypes of a mutant

  • a ''[gene|6F21B5E9EEF67E96808A1DEFA3A80DA2A0FF9462|pftA]-[gene|F6C3B267106E7510FABECF0B13ABF222901689A9|pftB]'' mutant is delayed in pellicle formation [Pubmed|26060272]
  • a ''[gene|7DA08C189F5524D4874E2F4828264AB2671A5460|ywbH]-[gene|2940E73F0BCAB69992BBD224402C95C2667757AD|ywbG] [gene|E5E431AC5A7D03EEFF6D694CB25EED1570D739A2|yxaK]-[gene|5A43EDB738641C675D4136269F3638F9B609F238|yxaC] [gene|6F21B5E9EEF67E96808A1DEFA3A80DA2A0FF9462|pftA]-[gene|F6C3B267106E7510FABECF0B13ABF222901689A9|pftB]'' triple mutant is severely delayed in pellicle formation [Pubmed|26060272]

    • The protein

    Protein family

  • LrgB subfamily (according to Swiss-Prot)

    • [SW|Localization]

  • cell membrane (according to UniProt)

    • Expression and Regulation

    Operons

    genes
    [gene|6F21B5E9EEF67E96808A1DEFA3A80DA2A0FF9462|pftA]-[gene|F6C3B267106E7510FABECF0B13ABF222901689A9|pftB]
    description
    [Pubmed|21815947]

    regulatory mechanism

  • [protein|53BA24E91EEC797C95B8975C487F3C50CBBFA2E3|LytT]: activation, [Pubmed|28974613,27422364], in [regulon|53BA24E91EEC797C95B8975C487F3C50CBBFA2E3|LytT regulon]
  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, ([Pubmed|28974613,27422364], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]
  • [protein|65E2F7197D46F5C884CC96018EE4F3EEE94FFA18|Kre]: repression, in [regulon|65E2F7197D46F5C884CC96018EE4F3EEE94FFA18|Kre regulon]

    • regulation

  • induced by acetate [Pubmed|26060272]
  • induced by pyruvate ([protein|53BA24E91EEC797C95B8975C487F3C50CBBFA2E3|LytT]) [pubmed|28974613]
  • subject to carbon catabolite repression ([protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]) [pubmed|28974613]

    • additional information

  • the [gene|6F21B5E9EEF67E96808A1DEFA3A80DA2A0FF9462|pftA]-[gene|F6C3B267106E7510FABECF0B13ABF222901689A9|pftB] operon is strongly upregulated in a ''[SW|kre]'' mutant [Pubmed|26110430]
  • the [gene|6F21B5E9EEF67E96808A1DEFA3A80DA2A0FF9462|pftA]-[gene|F6C3B267106E7510FABECF0B13ABF222901689A9|pftB] operon is strongly upregulated in a ''[SW|cshA]'' mutant [Pubmed|23175651]
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    Biological materials

    Mutant

  • MGNA-A983 (ysbB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/983 NBRP B. subtilis, Japan]
  • GP1554 (''[gene|6F21B5E9EEF67E96808A1DEFA3A80DA2A0FF9462|pftA]-[gene|F6C3B267106E7510FABECF0B13ABF222901689A9|pftB]''::''spc''), available in [SW|Jörg Stülke]'s lab

    • References

  • 26060272,23175651,21815947,8969504,26110430,27422364