yxdK [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

two-component sensor kinase, regulation of the ABC transporter YxdL-YxdM in response to the cationic antimicrobial peptide, LL-37

locus: BSU39650

pI: 6.23

mw: 37.00 kDa

function: resistance against toxic peptides

product: two-component sensor kinase

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]

[SW|Categories] containing this gene/protein

• [SW|protein modification], [SW|transcription factors and their control], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins], [SW|phosphoproteins]

Gene

Coordinates on the chromosome (coding sequence): 4,071,310 -> 4,072,287

Phenotypes of a mutant

• defective in the the ability to support the growth of ''Synechococcus leopoliensis'' CCAP1405/1 on agar media [Pubmed|25875741]

The protein

Catalyzed reaction/ biological activity

• autophosphorylation, phosphorylation of [protein|search|YxdJ]

[SW|Domains]

• two transmembrane segments, C-terminal histidine phosphotransferase domain

Modification

• autophosphorylation on a His residue

Expression and Regulation

Operon

• ''[protein|search|yxdJ]-[protein|search|yxdK]'' [Pubmed|10746760]

References

• 10094672,10746760,17600057,21283517,21078927,25875741