involved in polyketide synthesis
function
polyketide synthesis
product
hydroxymethylglutaryl CoA synthase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds][SW|Categories] containing this gene/protein
[SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|CodY regulon]Gene
Coordinates on the chromosome (coding sequence)
1,789,943 -> 1,791,205
The protein
Protein family
HMG-CoA synthase family (according to Swiss-Prot)Structure
[PDB|4YXQ][PDB|4YXT] (E82A mutant)[PDB|4YXV] (C114A mutant)Expression and Regulation
Operon
''[protein|search|pksC]-[protein|search|pksD]-[protein|search|pksE]-[protein|search|acpK]-[protein|search|pksF]-[protein|search|pksG]-[protein|search|pksH]-[protein|search|pksI]-[protein|search|pksJ]-[protein|search|pksL]-[protein|search|pksM]-[protein|search|pksN]-[protein|search|pksR]'' [Pubmed|22383849]Regulation
expressed during the transition from growth to stationary phase ([protein|search|AbrB], [protein|search|CodY]) [Pubmed|24187085]expression during spore [SW|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]Regulatory mechanism
[protein|search|AbrB]: transcription repression [Pubmed|24187085][protein|search|CodY]: transcription activation [Pubmed|24187085]References
23840410,22383849,24187085,27766092 
