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pksI [Tue Oct 25 2016 17:08:05 GMT+0200 (CEST)]
involved in polyketide synthesis
function
polyketide synthesis
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds][SW|Categories] containing this gene/protein
[SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|CodY regulon]Gene
Coordinates on the chromosome (coding sequence)
1,792,012 -> 1,792,761
The protein
Protein family
enoyl-CoA hydratase/isomerase family (according to Swiss-Prot)Structure
[PDB|4Q1G] and [PDB|4Q1H] (wildtype with different buffer components co-crystallized)[PDB|4Q1I] (A80K)[PDB|4Q1J] (A230H)[PDB|4Q1K] (A232K)Expression and Regulation
Operon
''[protein|search|pksC]-[protein|search|pksD]-[protein|search|pksE]-[protein|search|acpK]-[protein|search|pksF]-[protein|search|pksG]-[protein|search|pksH]-[protein|search|pksI]-[protein|search|pksJ]-[protein|search|pksL]-[protein|search|pksM]-[protein|search|pksN]-[protein|search|pksR]'' [Pubmed|22383849]Regulation
expressed during the transition from growth to stationary phase ([protein|search|AbrB], [protein|search|CodY]) [Pubmed|24187085]Regulatory mechanism
[protein|search|AbrB]: transcription repression [Pubmed|24187085][protein|search|CodY]: transcription activation [Pubmed|24187085]References
