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feuC [2017-11-16 15:17:46]
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feuC [2017-11-16 15:17:46]

ABC transporter for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein)
locus
BSU01610
pI
10.44
mw
42.91 kDa
protein length
394 aa Sequence Blast
gene length
1182 bp Sequence Blast
function
acquisition of iron
product
ABC transporter for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein)
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    180,344 → 181,354

    The protein

    Protein family

  • FecCD subfamily (according to Swiss-Prot)

    • [SW|Localization]

  • cell membrane [Pubmed|10092453]

    • Expression and Regulation

    Operons

    genes
    [gene|516B13F337FD346B4A4A268E35D1EBABB05957E1|feuA]-[gene|57402D137E3D3791CAF0696421224F4E1DC1BA48|feuB]-[gene|F38F6D4841B3044EA0496B3A1C1D484018BDFEA4|feuC]-[gene|745167427618C4DA71848F9362043B66BC4E392E|ybbA]
    description
    [Pubmed|12354229]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17725565], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [pubmed|12354229], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon]
  • [protein|EB28A65CECE994DF2DF486DEACF40F2533703DB0|Btr]: activation, in the presence of the co-activators bacillibactin or enterobactin [Pubmed|17725565], in [regulon|EB28A65CECE994DF2DF486DEACF40F2533703DB0|Btr regulon]

    • regulation

  • expression during spore [SW|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]
  • induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]) [pubmed|29133393]
  • expression of the operon is strongly induced at the beginning of [SW|biofilm formation] [pubmed|31113899]

    • additional information

  • the presence of an iron-responsive element bound by [SW|CitB] between ''[SW|feuA]'' and ''[SW|feuB]'' suggests iron-dependent regulation by [SW|CitB] [Pubmed|10468622]
    • view in new tab

    Other regulations

  • [protein|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB]: translation control,

    • Biological materials

    Mutant

  • BKE01610 (Δ[gene|F38F6D4841B3044EA0496B3A1C1D484018BDFEA4|feuC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE01610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAGCGATGAACAATGCAT, downstream forward: _UP4_AAGCAAAAAAAGGGGGAGAA
  • BKK01610 (Δ[gene|F38F6D4841B3044EA0496B3A1C1D484018BDFEA4|feuC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK01610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAGCGATGAACAATGCAT, downstream forward: _UP4_AAGCAAAAAAAGGGGGAGAA

    • References

  • 19746494,16672620,10092453,16889643,17725565,12354229,10468622