ywqL [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

endonuclease V

locus: BSU36170

pI: 5.00

mw: 26.00 kDa

function: DNA repair

product: endonuclease V

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.5|Newly identified sporulation proteins (based on transcription profiling)]

[SW|Categories] containing this gene/protein

• [SW|DNA repair/ recombination], [SW|sporulation proteins]

Gene

Coordinates on the chromosome (coding sequence): 3,724,420 -> 3,725,136

Phenotypes of a mutant

• increased mutation rates [Pubmed|22056936]
• increased sensitivity of sporulating cells to the genotoxic effects of nitrous acid[Pubmed|27698084]

The protein

Catalyzed reaction/ biological activity

• Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate (according to Swiss-Prot)

Protein family

• endonuclease V family (according to Swiss-Prot)

Structure

• [PDB|3GA2]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|ywqH]-[protein|search|ywqI]-[protein|search|ywqJ]-[protein|search|ywqK]-[protein|search|ywqL]'' [Pubmed|22383849]
• ''ywqL'' [Pubmed|9353933]

Regulation

• expressed throughout growth and staionary phase [Pubmed|22056936]

References

• 9353933,22056936,22383849,27530626,27698084