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manR [2019-06-25 11:17:03]
transcriptional activator of the manP-manA-yjdF operon
function
regulation of mannose utilization
product
transcriptional activator, PRD-type
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.9|Utilization of mannose][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.3|PRD-type regulators][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]Gene
Coordinates
1,270,631 → 1,272,577
The protein
Protein family
[SW|transcriptional antiterminator BglG family] (according to UniProt)Modification
phosphorylation by [protein|575CEC5C5C0458DC86A74F24654AC6990CB1E732|ManP] inactivates [protein|F273002AF97D87BB025B4F014C328C5592EAD621|ManR] (in the absence of mannose), phosphorylation by [gene|29B793660E4D30C0656248F3EF403FEF76FB9025|HPr] stimluates [protein|F273002AF97D87BB025B4F014C328C5592EAD621|ManR] [Pubmed|20139185]Expression and Regulation
Operons
genes
[gene|F273002AF97D87BB025B4F014C328C5592EAD621|manR]
description
[Pubmed|20139185]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|20139185], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|F273002AF97D87BB025B4F014C328C5592EAD621|ManR]: activation, in the presence of mannose and absence of glucose [Pubmed|20139185], in [regulon|F273002AF97D87BB025B4F014C328C5592EAD621|ManR regulon][protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|22900538], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]regulation
induced by mannose ([protein|search|ManR]) [Pubmed|20139185]view in new tabBiological materials
Mutant
MGNA-A269 (yjdC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/269 NBRP B. subtilis, Japan]BKE12000 (Δ[gene|F273002AF97D87BB025B4F014C328C5592EAD621|manR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE12000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGTTTTTCTATCCTTC, downstream forward: _UP4_TAAAAGCAGGGATTATTCCTBKK12000 (Δ[gene|F273002AF97D87BB025B4F014C328C5592EAD621|manR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK12000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGTTTTTCTATCCTTC, downstream forward: _UP4_TAAAAGCAGGGATTATTCCTReferences
10627040,20139185,9663674,22900538,23551403