transcriptional activator of the manP-manA-yjdF operon
function
regulation of mannose utilization
product
transcriptional activator, PRD-type
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.9|Utilization of mannose][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.3|PRD-type regulators][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|transcription factors and their control], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|ManR regulon]Gene
Coordinates on the chromosome (coding sequence)
1,270,631 -> 1,272,577
The protein
Modification
phosphorylation by [protein|search|ManP] inactivates [protein|search|ManR] (in the absence of mannose), phosphorylation by [ptsH|search|HPr] stimluates [protein|search|ManR] [Pubmed|20139185][SW|Interactions]
[protein|search|ManP]-[protein|search|ManR] [Pubmed|20139185][ptsH|search|HPr]-[protein|search|ManR] [Pubmed|20139185]Expression and Regulation
Operon
''[protein|search|manR]'' [Pubmed|20139185][SW|Sigma factor]
[protein|search|SigA] [Pubmed|20139185]Regulation
induced by mannose ([protein|search|ManR]) [Pubmed|20139185]repressed by glucose ([protein|search|CcpA], [protein|search|ManR]) [Pubmed|22900538,20139185]Regulatory mechanism
[protein|search|ManR]: transcription activation in the presence of mannose and absence of glucose [Pubmed|20139185][protein|search|CcpA]: transcription repression [Pubmed|22900538]References
10627040,20139185,9663674,20139185,22900538,23551403 
