O-acetylserine-thiol-lyase
function
methionine-to-cysteine conversion
product
O-acetylserine-thiol-lyase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.9|Biosynthesis/ acquisition of cysteine][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]This gene is a member of the following [SW|regulons]
[SW|CymR regulon], [SW|Spx regulon]Gene
Coordinates on the chromosome (coding sequence)
2,786,142 -> 2,787,065
The protein
Catalyzed reaction/ biological activity
O(3)-acetyl-L-serine + L-homocysteine = L-cystathionine + acetate (according to Swiss-Prot)Protein family
cysteine synthase/cystathionine beta-synthase family (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|yrrT]-[protein|search|mtnN]-[protein|search|mccA]-[protein|search|mccB]-[protein|search|yrhC]'' [Pubmed|17056751][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16513748]Regulation
repressed in the presence of cysteine ([protein|search|CymR]) [Pubmed|16513748]Regulatory mechanism
[protein|search|CymR]: transcription repression [Pubmed|16513748][protein|search|Spx]: transcription activation [Pubmed|12642660,16885442]Biological materials
Mutant
1A945 ( ''mccA''::''kan''), [Pubmed|17056751], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A945&Search=1A945 BGSC]References
17056751,16513748,16885442,12642660 
