polY2 [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

translesion synthesis (TLS-) DNA polymerase Y2

locus: BSU23710

pI: 9.53

mw: 45.00 kDa

function: UV-targeted mutagenesis

product: translesion synthesis (TLS-) DNA polymerase Y2

essential: no

synonyms: yqjW

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]

[SW|Categories] containing this gene/protein

• [SW|DNA repair/ recombination]

This gene is a member of the following [SW|regulons]

• [SW|LexA regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,464,562 -> 2,465,800

The protein

Catalyzed reaction/ biological activity

• Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)

Protein family

• DNA polymerase type-Y family (according to Swiss-Prot)

Paralogous protein(s)

• [SW|PolY1], [protein|search|UvrX], [protein|search|YozK]-[protein|search|YobH]

[SW|Interactions]

• [SW|PolY2]-[protein|search|DnaN] (required for untargeted mutagenesis) [Pubmed|15469515]
• [protein|search|PolA]-[SW|PolY2] [Pubmed|16045613]

Expression and Regulation

Operon

• ''[SW|polY2]-[protein|search|yqjX]'' (according to [http://dbtbs.hgc.jp/COG/prom/yqjWX.html DBTBS])

Regulation

• induced upon DNA damage ([protein|search|LexA]) [Pubmed|15469515,16267290]

Regulatory mechanism

• [protein|search|LexA]: transcription repression [Pubmed|15469515,16267290]

Biological materials

Mutant

• GP1505 (''polY2''::''kan''), available in [SW|Stülke] lab

References

Reviews

• 22933559

Original publications

• 16267290,12644484,15469515,16045613,19924481,23686288