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desR [Thu Dec 15 2016 14:43:22 GMT+0100 (CET)]
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desR [Thu Dec 15 2016 14:43:22 GMT+0100 (CET)]

two-component response regulator, regulation of cold shock expression of des
locus
BSU19200
pI
4.00
mw
22.00 kDa
function
regulation of cold shock expression of des
product
two-component response regulator
essential
no
synonyms
yocG
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.3|Lipid metabolism/ other]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.5|Cold stress proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]

    • [SW|Categories] containing this gene/protein

  • [SW|lipid metabolism/ other], [SW|transcription factors and their control], [SW|cold stress proteins], [SW|membrane proteins], [SW|phosphoproteins]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,091,705 -> 2,092,304

    The protein

    Catalyzed reaction/ biological activity

  • transcription activation of the ''[protein|search|des]'' operon when phosphorylated by [protein|search|DesK]

    • Modification

  • phosphorylated by [protein|search|DesK] on an Asp residue

    • Structure

  • [PDB|5IUJ]([SW|DesK]-[SW|DesR] complex in the phosphotransfer state with low Mg2 [20 mM]) [Pubmed|27938660]
  • [PDB|5IUK]([SW|DesK]-[SW|DesR] complex in the phosphotransfer state with high Mg2 [150 mM] and BeF3) [Pubmed|27938660]
  • [PDB|5IUN]([SW|DesK]-[SW|DesR] complex in the phosphatase state) [Pubmed|27938660]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • [SW|Interactions]

  • [protein|search|DesK]-[protein|search|DesR] [Pubmed|27938660]

    • Expression and Regulation

    Operon

  • ''[protein|search|desK]-[protein|search|desR]'' [Pubmed|11285232]

    • Regulation

  • induced by cold shock (18-fold) [Pubmed|12399512]

    • Biological materials

    Mutant

  • MGNA-A320 (yocG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/320 NBRP B. subtilis, Japan]

    • Labs working on this gene/protein

  • [SW|Diego de Mendoza], Universidad Nacional de Rosario, Argentine [http://www.ibr.gov.ar/eng/investigacion/demendoza.htm homepage]

    • References

  • 10094672,12399512,19595746,11285232,17087771,12207704,25406381,27938660