anti-SigD, regulation of flagellin, motility and chemotaxis
function
control of SigD activity
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.5|Additional chemotaxis signal transduction and regulatory proteins][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][SW|Categories] containing this gene/protein
[SW|sigma factors and their control], [SW|motility and chemotaxis]This gene is a member of the following [SW|regulons]
[SW|ComK regulon], [SW|DegU regulon], [SW|ScoC regulon], [SW|SigD regulon]Gene
Coordinates on the chromosome (coding sequence)
3,640,285 -> 3,640,551
The protein
Protein family
flgM family (according to Swiss-Prot)[SW|Localization]
secreted and extracellularly degraded by the proteases [protein|search|Epr] and [protein|search|WprA] [Pubmed|25313396]secretion of FlgM requires the [protein|search|FliF]/[protein|search|FliG] basal body proteins, the flagellar type III export apparatus components [protein|search|FliO], [protein|search|FliP], [protein|search|FliQ], [protein|search|FliR], [protein|search|FlhA], and [protein|search|FlhB], and the substrate specificity switch regulator [protein|search|FliK] [Pubmed|25313396][SW|Interactions]
[protein|search|FlgM]-[protein|search|SigD] [Pubmed|10207036]Expression and Regulation
Operon
''[SW|comFA]-[SW|comFB]-[SW|comFC]-[protein|search|yvyF]-[protein|search|flgM]-[protein|search|flgN]-[protein|search|flgK]-[protein|search|flgL]'' [Pubmed|8412657]''[protein|search|yvyF]-[protein|search|flgM]-[protein|search|flgN]-[protein|search|flgK]-[protein|search|flgL]'' [Pubmed|8045879]''[protein|search|flgM]-[protein|search|flgN]-[protein|search|flgK]-[protein|search|flgL]'' [Pubmed|21736639][SW|Sigma factor]
''[SW|comFA]'': [protein|search|SigA] [Pubmed|8412657]''[protein|search|yvyF]'': [protein|search|SigD] [Pubmed|8045879]''[protein|search|flgM]'': [protein|search|SigD] [Pubmed|21736639]Regulatory mechanism
[protein|search|ComK]: transcription activation [Pubmed|8412657][protein|search|ScoC]: transcription repression [Pubmed|19898538]''[protein|search|flgM]'': [protein|search|DegU]-P: transcription activation [Pubmed|21736639]Biological materials
Mutant
1A764 (no resistance), [Pubmed|8045879], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A764&Search=1A764 BGSC]References
Reviews
Original Publications
8955328,19898538,8412657,8045879,20233303,10207036,8655488,23352839,21736639,25313396,26244495 
