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hbs [Mon Aug 31 2015 13:55:18 GMT+0200 (CEST)]
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hbs [Mon Aug 31 2015 13:55:18 GMT+0200 (CEST)]

non-specific DNA-binding protein Hbsu
locus
BSU22790
pI
9.50
mw
9.00 kDa
function
DNA packaging, function of the signal recognition complex
product
non-specific DNA-binding protein Hbsu
essential
yes
synonyms
dbpA, hupA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue]
    • syns
    dbpA, hupA

    [SW|Categories] containing this gene/protein

  • [SW|DNA condensation/ segregation], [SW|essential genes], [SW|membrane proteins], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|LexA regulon], [SW|SigH regulon]

    • Gene

    Phenotypes of a mutant

  • essential [Pubmed|12682299,1382620]

    • The protein

    Catalyzed reaction/ biological activity

  • [protein|search|Hbs]-mediated untwisting of the DNA stimulates [protein|search|Nth] endonuclease activity at AP sites [Pubmed|21954439]

    • Protein family

  • DbpA subfamily (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|YonN]

    • Modification

  • phosphorylated on Arg-61 [Pubmed|22517742]
  • phosphorylation on Thr-4 [Pubmed|17218307]

    • Structure

  • [PDB|1HUU] (Geobacillus stearothermophilus)

    • [SW|Localization]

  • associated with the nucleoid in vegetative cells and forespores [Pubmed|9068655,10715001]
  • membrane associated [Pubmed|18763711]

    • Expression and Regulation

    Operon

  • ''hbs'' [Pubmed|1902464]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1902464], [protein|search|SigH] [Pubmed|1902464]

    • Regulation

  • induced by DNA damage ([protein|search|LexA]) [Pubmed|16267290]
  • strongly repressed in response to glucose starvation in M9 medium [Pubmed|23033921]

    • Regulatory mechanism

  • [protein|search|LexA]: transcription repression [Pubmed|16267290]

    • Biological materials

    two-hybrid system

  • B. pertussis adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Fabian Commichau]'s lab

    • Labs working on this gene/protein

  • [SW|Ciaran Condon], IBPC, Paris, France [http://www.ibpc.fr/UPR9073/condon/index_en.html Homepage]
  • [SW|Mohamed Marahiel], University of Marburg, Germany [http://www.uni-marburg.de/fb15/ag-marahiel/Prof.%20Dr.%20Mohamed%20A.%20Marahiel Homepage]

    • References

    Reviews

  • 11931565

    • Original publications

  • 1382620,1902464,10715001,9068655,9894920,16267290,19458035,19210617,18763711,17218307,21954439,22517742,23033921,10231583,8748031,7852372,9106208