parB [Sun Feb 19 2017 11:51:24 GMT+0100 (CET)]

chromosome positioning near the pole and transport through the polar septum / antagonist of SMC complex to the origin of replication

Locus: BSU40960

Isoelectric point: 8.00

Molecular weight: 32.00 kDa

Function: chromosome positioning before asymmetric septation,

Product: centromer-binding protein

Essential: no

Synonyms: spo0J, spo0JB

Genomic Context

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Categories containing this gene/protein

• Information processing → Genetics → DNA condensation/ segregation
• Lifestyles → Sporulation → Sporulation/ other

Categories containing this gene/protein

• DNA condensation/ segregation, sporulation/ other

This gene is a member of the following regulons

• Spo0A regulon

Gene

Coordinates on the chromosome (coding sequence): 4,205,556 -> 4,206,404

The protein

Catalyzed reaction/ biological activity

• inhibits ParA dimerization and concomitant DNA-binding activity by stimulating ParA ATPase activity PubMed
• recruits the condensin complex to the DNA origin region PubMed
• the dimer binds specifcally to the centromere-like parS sequence PubMed

Protein family

• parB family (according to Swiss-Prot)

Paralogous protein(s)

• Noc

Structure

• 4UMK (complex with parS DNA)

Localization

• chromosome centromer PubMed

Interactions

• forms dimers PubMed
• ParA-ParB PubMed

Expression and Regulation

Operon

• parA-parB PubMed

Regulation

• repressed under conditions that trigger sporulation (Spo0A) PubMed

Regulatory mechanism

• Spo0A: transcription repression PubMed

Biological materials

Mutant

• 1S135 ( spo0J::spec), [Pubmed| ], available at BGSC
• 1S136 ( spo0J::spec), [Pubmed| ], available at BGSC
• 1S137 ( spo0J::spec), [Pubmed| ], available at BGSC

Labs working on this gene/protein

• Heath Murray, Centre for Bacterial Cell Biology, Newcastle, UK homepage

References

Reviews

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Original publications

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