chromosome positioning near the pole and transport through the polar septum / antagonist of SMC complex to the origin of replication
function
chromosome positioning before asymmetric septation,
product
centromer-binding protein
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.3|Sporulation/ other][SW|Categories] containing this gene/protein
[SW|DNA condensation/ segregation], [SW|sporulation/ other]This gene is a member of the following [SW|regulons]
[SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
4,205,556 -> 4,206,404
The protein
Catalyzed reaction/ biological activity
inhibits [protein|search|ParA] dimerization and concomitant DNA-binding activity by stimulating [protein|search|ParA] ATPase activity [Pubmed|21235642]recruits the condensin complex to the DNA origin region [Pubmed|24440393]the dimer binds specifcally to the centromere-like ''parS'' sequence [Pubmed|25572315]Protein family
parB family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|Noc]Structure
[PDB|4UMK] (complex with ''parS'' DNA)[SW|Localization]
chromosome centromer [Pubmed|23475963][SW|Interactions]
forms dimers [Pubmed|24829297][protein|search|ParA]-[protein|search|ParB] [Pubmed|21235642]Expression and Regulation
Operon
''[protein|search|parA]-[protein|search|parB]'' [Pubmed|22383849]Regulation
repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]Regulatory mechanism
[SW|Spo0A]: transcription repression [Pubmed|14651647]Biological materials
Mutant
1S135 ( ''spo0J''::''spec''), [Pubmed| ], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S135&Search=1S135 BGSC]1S136 ( ''spo0J''::''spec''), [Pubmed| ], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S136&Search=1S136 BGSC]1S137 ( ''spo0J''::''spec''), [Pubmed| ], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S137&Search=1S137 BGSC]Labs working on this gene/protein
[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]References
Reviews
22934648,26706151,28075389 Original publications
17462018,16677298,12562803,10852876,10482533,9506522,8071208,17932079,21235642,26253537,9663676,11532141,19450516,15659156,18854156,9159397,8866474,9778525,16925562,1900505,9364919,9701805,12950914,14651647,19450517,19450516,14563866,23475963,21911367,24440393,24829297,24696501,25071173,25572315,25951515,26295962,28154080 
