tyrosyl-tRNA synthetase (major)
product
tyrosyl-tRNA synthetase (major)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|T-box]Gene
Coordinates on the chromosome (coding sequence)
3,036,603 -> 3,037,871
Phenotypes of a mutant
essential [Pubmed|12682299]the gene can be deleted, but the mutant acquires suppressors in ''[protein|search|dtrR]'' to allow expression of ''[protein|search|tyrZ]'' [Pubmed|25733610]a ''[protein|search|tyrS] [protein|search|tyrZ]'' double mutant is not viable [Pubmed|25733610]The protein
Structure
[PDB|3TS1] (complex with tyrosyl adenylate intermediate, Geobacillus stearothermophilus)[PDB|1JH3] (C-terminal domain, Geobacillus stearothermophilus)[PDB|1N53] (the [protein|search|T-box] antiterminator RNA) [Pubmed|12547201]Expression and Regulation
Operon
''[protein|search|tyrS]'' [Pubmed|1735721][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1735721]Regulation
induced by tyrosine limitation ([protein|search|T-box]) [Pubmed|19258532]Regulatory mechanism
[protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|19258532]Additional information
belongs to the 100 [[most abundant proteins]] [PubMed|15378759]References
Reviews
19258532,10546897,11163353 Original publications
9098057,12547201,11842119,10943892,9282752,8045882,8348614,1735721,8289305,20110252,21333656,15378759,25733610,25733611 
